Study aim: Comparison of Clonazepam and Lorazepam in the Treatment of methamphetamine-Poisoned Children Design: single blind, parallel group randomized-controlled clinical trial with 30 cases are divided into 2 groups of oral Clonazepam or Lorazepam according to the random numbers each of them include 15 case. ________________________________________ Settings and conduct: In this double blind, randomized-controlled clinical trial, which is done to investigate the effect of oral benzodiazepin (Clonazepam or Lorazepam), in children under 12 year-old with methamphetamine poisoning who presented to pediatrics emergency department, Loghman Hakim hospital, Iran, according to the inclusion and exclusion criteria.After filling the permission form with parents according to the random numbers software, 30 patients are divided into 2 groups of fifteen. After initial administration of 0.2-mg/Kg intravenous Diazepam, oral benzodiazepines ( 0.05 mg/kg Clonazepam or Lorazepam) were only given once to prevent return of stimulant toxicity. Oral benzodiazepines were given when the patient was calm, and could be switched to oral regimen. Vital signs and clinical symptoms are recorded Upon arrival then every 6 hours. Participants/Inclusion and exclusion criteria: Inclusion criteria: Children under 12-year-old age with methamphetamine poisoning exclusion criteria: Multiple-drug poisoning Intervention groups: After initial administration of 0.2-mg/Kg intravenous Diazepam, oral benzodiazepines ( 0.05 mg/kg Clonazepam or Lorazepam) were only given once to prevent return of stimulant toxicity. Oral benzodiazepines were given when the patient was calm, and could be switched to oral regimen. Main outcome variables: Agitation level; duration of hospital stay; side effects of treatment (respiratory depression, deep sedation, paradoxical agitation).