IRCT2015111611662N8 IRCT 2015-12-17 Vice-Chancellery of Research and Technology Effect of oral mixture of midazolam and ketamin with oral mixture of meperidine and chloral hydrate on calmness and post operative pain in pediatric tonsillectomy surgery. Comparison the effect of oral mixture of midazolam and ketamin with oral mixture of meperidine and cholral hydrate in agitation and post operative pain in pediatric patients undergoing tonsillectomy 2015-10-23 anticipated 64 Complete https://irct.ir/trial/11836 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive. N/A pain following tonsillectomy. Intervention 1: In the group one pediatrics will be received oral mixture midazolam and ketamine mg/kg 30 min before going to operation room. Intervention 2: in the 2nd group pediatrics will be received oral mixture of meperidine mg/kg and chloral hydrate mg/kg 30 min before operation.

public Mohammad Ali Sahmeddini

Shiraz Anesthesilology and critical care Research center, Namazi Hospital, Namazi Sq.

Shiraz Iran (Islamic Republic of) 1135171937 +98 71 3647 4270 sahmeddini@sums.ac.ir Shiraz University Of Medical Sciences scientific Mohammad Ali Sahmeddini

Shiraz Anesthesiology and Critical Care Center, Namazi Hospital, Namazi Sq

Shiraz Iran (Islamic Republic of) 7193711351 +98 71 3647 4270 sahmeddini@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) 64 pediatrics patients who will be candidate for elective tonsillectomy under general anesthesia will be enrolled in this study. Exclusion criteria are: emergency surgery; history of cardiopulmonary disorders; hypersensitivity to study's drugs; liver disease; kidney disease and history of convulsion. 3 years 8 years Both R07.0 Pain in throat Treatment - Drugs Treatment - Drugs In the group one pediatrics will be received oral mixture midazolam and ketamine mg/kg 30 min before going to operation room. in the 2nd group pediatrics will be received oral mixture of meperidine mg/kg and chloral hydrate mg/kg 30 min before operation Post operative pain. Timepoint: Every hour during first 6 hours post operation. Method of measurement: Backer-Wong-faces pain scale. Postoperative agitation. Timepoint: after awakening in recovery room. Method of measurement: according to this scale: 1.Asleep ;2. Awake but comfort ;3.Agitate ; 4.severly agitate and difficult to calm. Calmness during going to operatin theater. Timepoint: During seperation from parents and going to operation theater. Method of measurement: according to this scale: 1.Full awake-calm ; 2. crying ; 3. violent movement ; 4. Asleep. Nausea and Vomiting. Timepoint: Every one hour during first postoperative 6 hr. Method of measurement: Nausea is defined as urge to vomiting without ejection ofof the contents of the stomach through the mouth, Vomiting is defined asto eject of the contents of the stomach through the mouth, usually in a series of involuntary spasmic movements. Vice-Chancellery of Research and Technology Approved 2015-09-23 Shiraz Medica School Research Ethic Committee Shiraz Medical School -Zand Blv Shiarz Iran (Islamic Republic of)