IRCT2015062814333N37 IRCT 2015-07-24 Vice chancellor for research, Kermanshah University of Medical Sciences A Comparative study of the effect of Valsalva maneuver and EMLA cream on level of venous cannulation pain Comparing the effectiveness or ineffectiveness of Valsalva maneuver and EMLA cream on level of venous cannulation pain 2015-07-23 anticipated 160 Complete https://irct.ir/trial/13971 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Other, Other design features: Randomized by sealed envelope. N/A level of venous cannulation pain. Intervention 1: The first group made use of EMLA cream, made by Astrazeneca,Eczacibasi Ltd, Turkey. Cream surface is covered by a piece of paper and a 2 cc syringe was used to apply 1 cc, or 2.5 mlg, of the cream on dependent hand where venous cannulation was conducted at 2.5×2.5 cm. after 40 minutes, the dressing was removed from cannulation point and the place was disinfected using cotton drained in alcohol. Then, BP18 IVC was used to do venous cannulation while the patient lay back and his head is against the cannulation point. Also, tourniquet was placed on his forearm. Intervention 2: Valsalva maneuver in the second group was accomplished through blowing in a plastic pipe connected to a mercury barometer (Easylife, china) and holding up mercury bar upper than 20 mmHg for at least 20 seconds. Immediately after that venous cannulation was done similar to the group using EMLA cream. Intervention 3: Both EMLA cream and Valsalva maneuver were applied to the third group. 40 minutes after applying EMLA cream and in similar conditions to the first group, venous cannulation was done immediately after Valsalva maneuver. Intervention 4: All the conditions to the group using EMLA cream were considered to the fourth group. the difference is that Vaseline (Kimiagar-Toos Ltd, Iran) is used in the fourth group instead of EMLA cream. After 40 minutes venous cannulaton was accomplished.