<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT2014070518362N1</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2015-12-26</date_registration>
      <primary_sponsor>Ahvaz Jundishapur University of Medical Sciences, Vice Chancellor for Research Development and Techn</primary_sponsor>
      <public_title>Comparison of the Effects of  Knee and Hip Muscle Exercises and  Isolated Knee  Muscle Exercises in Treatment of Anterior Knee Pain</public_title>
      <acronym></acronym>
      <scientific_title>Comparison of the Effects of  Knee Exercises  and Knee Exercises with Additional Hip Strengthening Exercises on Landing Kinematics in Females with Patellofemoral Pain Syndrome</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2014-12-01</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>76</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/16672</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Table of random numbers will be used to simply assign the subjects in two groups of treatment&#13;
The examiner will not be aware of which intervention will be administered to which subject.&#13;
The patients aware of the existence of two different groups, but do not know about their groups (treatment or control).</study_design>
      <phase>N/A</phase>
      <hc_freetext>Patellofemoral Pain Syndrome.</hc_freetext>
      <i_freetext>Intervention 1: Intervention 1 : The treatment for the individuals in the knee exercise group includes stretching and strengthening of the knee musculature. Each individual will receive 12 sessions of treatment with the frequency of three sessions per week for 45 minutes. For strengthening exercises, the amount of load will be standardized to 70% of the 1-repetition maximum with no pain. For exercises using elastic band, the resistance will be standardized to the maximum resistance that each individual can use to complete 10 repetitions of the exercise. The maximum load and resistance will be determined in the first session, and will be evaluated weekly for any required adjustments. Stretching of the hamstrings and ankle plantar flexors, quadriceps, and iliotibial band will consist of three 30-second stretches, assisted by therapist. Intervention 2: Intervention 2 : Individuals in the knee and hip exercise group will perform the hip abductor and lateral rotator muscles strengthening exercises in addition to knee musculature stretching and strengthening exercises. Each individual will receive 12 sessions of treatment with the frequency of three sessions per week for 45 minutes. For strengthening exercises, the amount of load will be standardized to 70% of the 1-repetition maximum with no pain. For exercises using elastic band, the resistance will be standardized to the maximum resistance that each individual can use to complete 10 repetitions of the exercise. The maximum load and resistance will be determined in the first session, and will be evaluated weekly for any required adjustments. Stretching of the hamstrings and ankle plantar flexors, quadriceps, and iliotibial band will consist of three 30-second stretches, assisted by therapist.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan></results_IPD_plan>
      <results_IPD_description></results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Dr. Fateme Esfandiarpour</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>School of Rehabilitation Sciences, University Pardis, Golestan,</address>
        <city>Ahvaz</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip></zip>
        <telephone>+98 61 3374 3108</telephone>
        <email>esfandiarpour_f@ajums.ac.ir</email>
        <affiliation>Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Dr. Fateme Esfandiarpour</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>school of Rehabilitation Sciences, University Pardis, Golestan</address>
        <city>Ahvaz</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip></zip>
        <telephone>+98 61 3374 3108</telephone>
        <email>esfandiarpour_f@ajums.ac.ir</email>
        <affiliation>Ahvaz Jundishupur University of Medical Sciences, Ahvaz, Iran</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Inclusion Criteria: Females with PFPS in the age range of 18-45 years will be included in this study if they have a history of anterior or retropatellar knee pain with a severity of at least 30 on a 100  visual analogue scale (VAS) for at least the past 3 months, in 2 or more daily activities including: ascending and descending stairs, squatting, kneeling, jumping, long sitting, isometric knee extension, quadriceps contraction at 60° of knee flexion, and pain on palpation of the medial and/or lateral facet of the patella.&#13;
Exclusion Criteria: Subjects will be excluded if they have more than trace knee effusion, a history of patellar dislocation; surgery involving the patellofemoral joint; or signs or symptoms of meniscal pathology or other intra-articular conditions; cruciate or collateral ligament involvement; tenderness of the patellar tendon, the iliotibial band, and/or the pes anserinus tendon; positive patellar apprehension sign; Osgood-Schlatter or Sinding-Larsen-Johansson syndrome; hip pain, back pain, or sacroiliac joint pain. Subjects who have been diagnosed with any neuromuscular disorder of the lower extremity will also be excluded in this study.</inclusion_criteria>
      <agemin>18 years</agemin>
      <agemax>45 years</agemax>
      <gender>Female</gender>
      <exclusion_criteria></exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code>M22.2</hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword>Chondromalacia patellae</hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Rehabilitation</i_code>
      <i_code>Rehabilitation</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>Intervention 1 : The treatment for the individuals in the knee exercise group includes stretching and strengthening of the knee musculature. Each individual will receive 12 sessions of treatment with the frequency of three sessions per week for 45 minutes. For strengthening exercises, the amount of load will be standardized to 70% of the 1-repetition maximum with no pain. For exercises using elastic band, the resistance will be standardized to the maximum resistance that each individual can use to complete 10 repetitions of the exercise. The maximum load and resistance will be determined in the first session, and will be evaluated weekly for any required adjustments. Stretching of the hamstrings and ankle plantar flexors, quadriceps, and iliotibial band will consist of three 30-second stretches, assisted by therapist.</i_keyword>
      <i_keyword>Intervention 2 : Individuals in the knee and hip exercise group will perform the hip abductor and lateral rotator muscles strengthening exercises in addition to knee musculature stretching and strengthening exercises. Each individual will receive 12 sessions of treatment with the frequency of three sessions per week for 45 minutes. For strengthening exercises, the amount of load will be standardized to 70% of the 1-repetition maximum with no pain. For exercises using elastic band, the resistance will be standardized to the maximum resistance that each individual can use to complete 10 repetitions of the exercise. The maximum load and resistance will be determined in the first session, and will be evaluated weekly for any required adjustments. Stretching of the hamstrings and ankle plantar flexors, quadriceps, and iliotibial band will consist of three 30-second stretches, assisted by therapist.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Hip adduction and internal rotation angles. Timepoint: Before and after treatment interventions. Method of measurement: Motion Analysis System.</prim_outcome>
      <prim_outcome>Maximal Isometric Strength of Quadriceps Muscles. Timepoint: Before and after treatment interventions. Method of measurement: Handheld Dynamometer.</prim_outcome>
      <prim_outcome>Maximal Isometric Strength of Hamstring Muscles. Timepoint: Before and after treatment interventions. Method of measurement: Handheld Dynamometer.</prim_outcome>
      <prim_outcome>Maximal Isometric Strength of  Hip External Rotator and Abductor Muscles. Timepoint: Before and after treatment interventions. Method of measurement: Handheld Dynamometer.</prim_outcome>
      <prim_outcome>Knee dynamic valgus. Timepoint: Before and after treatment interventions. Method of measurement: Motion Analysis System.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome>Pain and Functional ability of lower extremity. Timepoint: Before and post treatment intervention. Method of measurement: Visual Analog Scale, Kujala Questionnaire.</sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Ahvaz Jundishapur University of Medical Sciences, Vice Chancellor for Research Development and Techn</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2015-04-29</approval_date>
        <contact_name>Ethics Committee of Ahvaz Jundishapur University of Medical Sciences</contact_name>
        <contact_address>Central Office, University Campus, Golestan Ahvaz  Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
