IRCT2015041720178N3 IRCT 2015-05-03 Iran University of Medical Sciences,Rasoul Akram Hospital,Colorectal Research Center Efficacy of vitB12 plus standard chronic HCV treatment versus standard chronic HCV treatment on sustained virologic response rate A comparison of vitB12 plus standard chronic HCV treatment with standard chronic HCV treatment on sustained virologic response rate 2015-03-21 anticipated 74 Complete https://irct.ir/trial/17892 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Chronic viral hepatitis C. Intervention 1: control:: Peg-IFNa2b 1.5 mg/kg/week subcutaneously and ribavirin ; according to body weight(1000 mg/day for weighing <75 kg, 1200 mg/day for weighing >75 kg in genotype 1 or 4 and a single ribavirin dose of 800 mg/day in genotype 2 or 3 . Intervention 2: Intervention: : Peg-IFNa2b 1.5 mg/kg/week subcutaneously and ribavirin ; according to body weight(1000 mg/day for weighing <75 kg, 1200 mg/day for weighing >75 kg in genotype 1 or 4 and a single ribavirin dose of 800 mg/day in genotype 2 or 3 plus vitamin B12 5000 microgram intramuscular injection every 4 weeks for the duration of the antiviral therapy.