IRCT201702282624N22 IRCT 2017-04-03 Vice chancellor for research ,Iran University of Medical Sciences. Induction of labor with 3 different methods. A comparison between induction of labor with 3 methods of titrated oral misoprostol, constant dose of oral misoprostol and folly catheter with extra amniotic saline infusion (EASI), in women with unfavorable cervix. 2014-04-05 anticipated 116 Complete https://irct.ir/trial/2427 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Condition 1: Delivery. Condition 2: Outcome of delivery. Intervention 1: In oral titrared misoprostol group: 200µg misoprostol tablet will be solved in 200 milliliter of water (this solution is stable in the room temperature and contains 1µg misoprostol in 1mlit of solution). First, 20 milt (20µg) of misoprostol will be administered hourly for 4 hours. Then in spite of not having good contractions, 40 milt (40µg) of misoprostol solution will be administered every 1 hour for 4 doses and will be repeated after 4 hours with 60mlit (60µg) of misoprostol solution for a maximum of 4 doses (in total 480µg). Intervention 2: In oral misoprostol group, 50µg misoprostol will be administered and women will be followed up to 4 hours. FHR and uterine contractions will be checked hourly. In the cases of not having suitable contractions after 4 hours, another 50 µg of misoprostol will be administered every 4 hours until obtaining good contractions or up to maximum 6 doses (300 µg totals). Then the women will be followed up to delivery. Intervention 3: In the EASI group, folly catheter of number 18 was introduced through cervical canal and was filled with 30mlit distilled water and was fixed above the internal cervical OS, and was connected to normal saline solution. The normal saline was entered the uterus with the rate of 30 drops per minute. After expulsion of folly catheter, oxytocin was started in the amount of 25 milliunits per minute and was increased every 15 minutes up to 40 milliunits per minute.