IRCT20171111037396N1 IRCT 2018-07-18 Shiraz University of Medical Sciences Prolotherapy in Knee Osteoarthritis Comparison of the effectiveness of intra-articular prolotherapy versus peri-articular prolotherapy on pain reduction and improving function in patients with knee osteoarthritis without effusion 2018-08-06 anticipated 60 Complete https://irct.ir/trial/29353 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomly allocate 60 eligible subjects to two parallel groups: Intra-articular injection as group A and Peri-articular injection as group B by the administrator of the clinician who educated to use a block randomization list. The list is made by computer as non-stratified list, with the equal block length. The patients will be not aware of being allocated in the group A or B. Also, statisticians will be kept blind about the allocation, Blinding description: Participants will be allocated by blocked randomization list to 2 groups by investigator A :Intraarticular prolotherapy and B:Periarticular prolotherapy. the patients will be not aware of being allocated in the group A or B. In both groups the investigator will inject the prolotherapy agent.The patients will be visited by a second colleague who will be not aware of the groups during the study.outcome assessor will be not blind but statisticians will be kept blind about the allocation. N/A Knee Osteoarthritis. Intervention 1: In the group A patient lies on bed, patient’s knee with placing a pillow under it flexes to 30 degrees then practitioner prepare the knee and injects 5 cc dextrose 25% from inferiolateral side of the knee joint by 23 gauge Syringe. Preparation of dextrose 25%( 2.5 cc lidocaine2% plus 2.5 cc dextrose 50%). Intervention 2: In the group B, 5 cc of dextrose 25% will be injected by using 25 gauge syringe around knee joint maximum in two points (lateral or medial). These points are the most painful points, except pesanserine bursitis. Preparation of dextrose 25%( 2.5 cc lidocaine2% plus 2.5 cc dextrose 50%). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information