IRCT20151128025267N6 IRCT 2018-07-11 Tehran University of Medical Sciences Evaluating the effects of vitamin D on migraine headache and its possible associated factors Evaluating the effects of viamin D on CGRP levels, inflammatory markers, Treg/Th17 balance and episodic migraine characteristics in Adult migraineurs 2018-06-22 anticipated 80 Complete https://irct.ir/trial/31246 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: The duration of this randomized, double-blind, placebo controlled trial will be 16 weeks, consisting of 4-week of baseline following by 12-week intervention. Also, patients will be instructed to fill out a headache diary designed by our headache specialist neurologist in order to provide headache characteristics including headache severity, duration of attacks, number of attacks, and number of days with headache in the month. Patients will be asked to not change their medications during the study, Randomization description: according to double-blind nature of this trial, from the beginning of the study, A and B codes are available to researchers to recruit the patients using twenty 4-Block Randomization, Blinding description: Only one of the staff of the headache department is aware of the type of assigned intervention for each patient (vitamin D or placebo, which are marked by A or B codes). Finally, after collecting the data, she unseals the codes for researchers, the statistical analyst, and those who prepare the manuscript. 0 (exploratory trials) migraine headache. Intervention 1: Intervention group: intervention group will receive 1 capsule which contains 2000 of vitamin D every day for 12 weeks. Intervention 2: Control group: placebo group will receive 1 capsule of placebo with the same smell and taste as vitamin D during 12-week period. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information