IRCT20140212016557N4 IRCT 2018-10-22 Shiraz University of Medical Sciences Comparison of the effect of cysteamine cream and hydroquinone cream in the treatment of melasma Comparison of the therapeutic efficacy of cysteamine 5% cream with Hydroquinon 4% cream in epidermal melasma patients 2018-03-16 anticipated 98 Complete https://irct.ir/trial/33526 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The participants were randomized using permuted block randomization (size of each block: 4), in individual units, using random allocation software. The medications are in the similar tubes labeled by numbers of the patients, Blinding description: Despite of close similarity of medications tubes, the participants cannot be blind because of the different instructions for use. Principle investigator, the drug presentation staff, and care provider physician are also aware of the type pf drugs. But, data collectors and outcome assessors are not aware of the medication of each patient. 3 Melasma. Intervention 1: Intervention group: Cysteamine 5% cream (Scentispharma, Switzerland) is applied once every night for 15 minutes for 4 months on the face skin. Intervention 2: Control group: آydroquinone 4% cream which is made by dissolution of 2 grams powder of hydroquinone (Merck, Germany) and 1.5 grams ascorbic acid powder (Merck, Germany) in 50 grams of vanishing cream (Minoo, Iran) is applied once every night overnight for 4 months on the face skin. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.