IRCT20140907019082N9 IRCT 2018-09-23 Vice chancellor for research , Tabriz University of Medical Sciences, Effect of oral thylakoid intake with low-calorie diet in the treatment of polycystic ovary syndrome ندارد The effects of oral thylakoid intake on the metabolic, hormonal and inflammatory parameters in obese women with polycystic ovary syndrome under hypocaloric diet: A randomized double-blinded placebo controlled trial 2018-08-29 anticipated 48 Complete https://irct.ir/trial/33619 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: From among the patients who volunteer to participate in the study, 48 individuals will be selected by simple randomization. Then by using the Random Allocation Software, the subjects will be allocated into either thylakoid or placebo group, stratified by age and body mass index (BMI), Blinding description: In this study, the main investigators (including the student, and her supervisor and adviser professors) as well as the patients will be blinded to the type of the supplement (thylakoid or placebo) received by each group. The person responsible for preparing the supplement sachets (who is completely unrelated to the study) will be asked to assign a three digit code to each of the two powders (prebiotic and placebo), and keep the codes for himself until the end of the study and data analyses. 3 Polycystic ovary syndrome. Intervention 1: Intervention group: Patients in this group will receive low-calorie diet with a thylakoid supplement for 12 weeks. Thylakoid supplement is a sachet containing 5 grams of thylakoid (extracted from spinach leaves and made by a researcher) which will be dissolved in a glass of water and used once a day with lunch. Intervention 2: Control group: Patients in this group will receive low-calorie diet and placebo for 12 weeks. Placebo is a sachet containing 5 grams of raw corn starch, which will be dissolved in a glass of water and used once a day with lunch. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Its release plan is still unknown