]>
IRCT138812123307N4 IRCT 2010-03-03 Pasteur Institute of Iran (IPI) Short term Efficacy and Safety of Alpha Interferon -2b (Pasture Made) plus Ribavirin for Treatment of the Patients with Chronic Hepatitis C Short term Efficacy and Safety of Alpha Interferon -2b (Pasture Made) plus Ribavirin for Treatment of the Patients with Chronic Hepatitis C 2010-04-01 anticipated 100 Complete https://irct.ir/trial/3378 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Chronic Hepatitis C. Subcutaneous treatment with Alpha Interferon -2b (Pasture Made) Every other day plus oral treatment with ribavirin 10-15 mg/kg per day for 24 to 48 weeks according to the genotype of virus..
public Mehrdad Nooranipour
Ground Floor of Baqiyatallah Hospital, Baqiyatallah Medical University, Mollasdra Ave., Vanak Squ
Tehran Iran (Islamic Republic of) +98 21 8861 4523 manager@hepmon.ir Baqiyatallah Research Center for Gastroenterology and Liver Diseases scientific Sayed Moayed Alavian
Ground Floor of Baqiyatallah Hospital, Baqiyatallah Medical University, Mollasdra Ave., Vanak Squ
Tehran Iran (Islamic Republic of) +98 21 8861 4523 editor@hepmon.ir Baqiyatallah Research Center for Gastroenterology and Liver Diseases Iran (Islamic Republic of) Inclusion Criteria: Impossibility for administration of peg-interferon according to recommendation of relevant specialist, older than 18 years, HCV RNA in serum on polymerase-chain-reaction (PCR) assay Exclusion Criteria: decompensated cirrhosis, autoimmune disease, evidence of cancer on ultrasonography or a high serum alfa-fetoprotein concentration, co-infection with HBV or HIV, neutropenia (neutrophil count <1500 cells/mm3), thrombocytopenia (platelet count <90,000 cells/mm3), anemia (hemoglobin level <12 gr/dl for women and <13 gr/dl for men), creatinine concentration more than 1.5 times the upper limit of normal range, organ transplantation, neoplastic disease, severe cardiac or chronic pulmonary disease, poorly controlled psychiatric disorder, seizure disorder, retinopathy, active drug or alcohol abuse, pregnancy in patient or spouse or unwillingness to use contraception. 18 years 100 years Both B18.2 Chronic viral hepatitis C Treatment - Drugs Subcutaneous treatment with Alpha Interferon -2b (Pasture Made) Every other day plus oral treatment with ribavirin 10-15 mg/kg per day for 24 to 48 weeks according to the genotype of virus. Rapid virologic response (RVR). Timepoint: 1 month after treatment initiation. Method of measurement: PCR. Sustained virologic response (SVR). Timepoint: Every 3 months. Method of measurement: PCR. Pasteur Institute of Iran (IPI) Approved Ethics committee of Baqyatallah University of Medical Sciences Baqyatallah University of Medical Sciences, Mollasdra Ave., Vanak Squ Tehran Iran (Islamic Republic of)