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IRCT20160702028742N5 IRCT 2019-04-19 Shahid Beheshti University of Medical Sciences Comparison of effects of refined olive oil and canola in patients referred for coronary angiography Comparison of effect of refined olive oil with canola oil consumption on plasma lipids and inflammatory cytokines secretion of whole blood culture in patients referred for coronary angiography 2019-01-01 anticipated 40 Complete https://irct.ir/trial/36418 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Other design features: -, Randomization description: Simple randomization method (the easiest method of randomization) using a random numbers table Random numbers table is a list of numbers, composed of the digits 0-9. Numbers in the list are arranged randomly, means that each number has no predictable relationship to the numbers that preceded it or to the numbers that followed it. At first, each member of study population (patients) has been assigned a number. Then, as regard to required sample size, it is randomly started from a point, moved systematically based on previous decision to the right, left, up or down, and the next number is selected. Based on previous decision, odd and even numbers are placed in the control and intervention groups, respectively. The random number allocation was concealed from the researcher and participants. N/A Coronary Artery Disease. Intervention 1: Intervention group: Daily consumption of 25 mL of pure canola oil as cold with meals for 6 weeks. Intervention 2: Intervention group: Daily consumption of 25 mL of refined olive oil as cold with meals for 6 weeks. https://lipidworld.biomedcentral.com/articles/10.1186/s12944-020-01362-z Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.
public Nafiseh Khandouzi
No. 46, Hafezi St, Farahzadi Blvd, Qods Town, Tehran
Tehran Iran (Islamic Republic of) 1981619573 +98 21 2207 7424 n-khandouzi@sbmu.ac.ir Shahid Beheshti University of Medical Sciences scientific Dr Javad Nasrollahzadeh
No. 46, Hafezi St, Farahzadi Blvd, Qods Town, Tehran
Tehran Iran (Islamic Republic of) 1981619573 +98 21 2207 7424 jnasrollahzadeh@gmail.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Existence of at least one of the major cardiovascular risk factors Willingness to participate in the study No consumption of any anti-inflammatory or antioxidant supplement such as omega-3, vitamin E, vitamin C and Selenium in last month 20 years 75 years Both Unwillingness to continue Any changes in disease treatment plan such as changes in medical treatment or surgery Existence of gastrointestinal complications such as diarrhea I25.1 Atherosclerotic heart disease of native coronary artery Lifestyle Lifestyle Intervention group: Daily consumption of 25 mL of pure canola oil as cold with meals for 6 weeks Intervention group: Daily consumption of 25 mL of refined olive oil as cold with meals for 6 weeks Lipoprotein-associated phospholipase A2 (Lp-PLA2). Timepoint: Baseline and the end of the study. Method of measurement: ELISA. Plasma Lipoproteins. Timepoint: Baseline and the end of the study. Method of measurement: colorimetry. Interleukin-6 (IL-6) & Monocyte Chemoattractant Protein-1 (MCP-1) in cultured whole blood. Timepoint: Baseline and the end of the study. Method of measurement: ELISA. Shahid Beheshti University of Medical Sciences Approved 2018-03-13 ٍEthics Committee of Shahid Beheshti University of Medical Sciences No. 46, West Arghavan Ave., Farahzadi Blvd., Qods Town Tehran Tehran Iran (Islamic Republic of)