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IRCT20141209020250N5 IRCT 2019-11-24 Tehran University of Medical Sciences The comparison of two regimens of diphencyprone in alopecia areata patients. Evaluation and comparison of the efficacy and safety of two regimens of diphencyclopropenone (applying different concentrations to identify the effective concentration vs. traditional method) in the treatment of alopecia areata in patients referred to Razi Hospital, 1398-1399. 2019-11-22 anticipated 60 Complete https://irct.ir/trial/43192 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization. 3 alopecia areata. Intervention 1: Intervention group1: 30 patients with alopecia areata who are receiving topical diphencyprone with new regimen. Intervention 2: Intervention group 2: 30 patients with alopecia areata who are receiving topical diphencyprone with old regimen. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Doctor Alaa Al Bazzal
Razi Dermatology Hospital, Razi blind Alley, Vahdate-Islami Square, Vahdate-Islami Street, Tehran
Tehran Iran (Islamic Republic of) 1199663911 +98 21 5560 9951 alabazal9@gmail.com Tehran University of Medical Sciences scientific doctor Alaa Al Bazzal
Razi Dermatology Hospital, Razi Blind Alley, Vahdate-Islami Square, Vahdate-Islami Street, Tehran
Tehran Iran (Islamic Republic of) 1199663911 +98 21 5560 9951 alabazal9@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Patients with alopecia areata Possibility of regular visit for the patient Hair loss more then 50 % The age of the patient greater than 18 years old 18 years no limit Both Pregnancy and lactation Persistent totalis or universalis areata alopecia from infancy Prominent androgenetic alopecia No response to diphencyprone test Patients with hematologic dysplasia receiving systemic immunosuppressive therapy during recent 3 months L63 Alopecia areata Treatment - Drugs Treatment - Drugs Intervention group1: 30 patients with alopecia areata who are receiving topical diphencyprone with new regimen. Intervention group 2: 30 patients with alopecia areata who are receiving topical diphencyprone with old regimen Terminal hair regrowth rate with topical diphencyprone with old regimen in comparison to new regimen in patients with alopecia areata, based of SALT score. Timepoint: before intervention and 3 and 6 months after intervention. Method of measurement: Severity of Alopecia Tool Score. Rate of change in Severity of Alopecia Tool score than the base value, after intervention and at the end of course of treatment. Timepoint: 3 and 6 months after treatment. Method of measurement: Severity of Alopecia Tool score. Tehran University of Medical Sciences Approved 2019-08-24 Ethics committee of Tehran University of Medical Sciences Fourth floor, No 23, before Poursina Street, 16 Azar Street, Keshavarz Boulevard Tehran Tehran Iran (Islamic Republic of)