IRCT20191123045474N1 IRCT 2019-11-26 Mashhad University of Medical Sciences Intraoperative radiotherapy during breast cancer surgery Results of intraoperative radiotherapy as a boost in non-metastatic breast cancer undergoing breast conservation surgery 2019-12-13 anticipated 50 Complete https://irct.ir/trial/43717 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Prevention. 2 Breast cancer. Intervention group: During breast-conserving surgery, patients will be treated with INTRABEAM 50-kV X-ray source at a dose of 20 Gy. Postoperatively, patients will receive systemic treatment according to the NCCN 2017 Clinical Guidelines as appropriate, including chemotherapy, hormone therapy, and targeted therapy. whole-breast external beam radiotherapy at a dose of 50 Gy and supraclavicular lymph node at a total dose of 45-50 Gy or hypofractionation to the whole breast at 16 sessions of 2.66 cGy will be subjected to hormone therapy if positive.. Yes - There is a plan to make this available What will be shared: All potential data is shared after unidentifiable people When: Start of access period 6 months after publication of results To whom: Researchers working in academic and scientific institutions Conditions: For future research purposes and data comparisons, future studies of data are available. Where to obtain: Contact Dr. Anvari, Project Manager, for request any data/document with AnvariK@mums.ac.ir and the address of Mashhad, Koohsangi Ave, Omid Hospital (postcode 9176613775). How to obtain: After submitting the request to the research team and the project coordinator, the request will be submitted to the Research Committee of the Oncology Radiotherapy Department of Mashhad University of Medical Sciences and decisions will be made on the success or rejection of the request. Comments: