IRCT20180909040979N5 IRCT 2020-01-03 Ahvaz University of Medical Sciences The effect of tranexamic acid and hydroquinone in melasma Comparison of the efficacy of intradermal injecting of tranexamix acid and hydroquinone cream in the treatment of melasma 2019-12-07 anticipated 48 Complete https://irct.ir/trial/44047 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Individuals are randomly divided into two groups based on block randomization method. Randomized blocks are used for this purpose. A random sample based on this method from Sealedenvelope.com has been extracted. 3 Melasma. Intervention 1: Intervention group 1: In group A, after application of topical anesthetic cream (lidocaine + prilocaine) 30 minutes before injection, tranexamic acid ampule, 100 mg/ml (manufactured by Caspian Supply Company) will be injected intradermally into melasma areas at 1 cm intervals, every 2 weeks for 3 months. The 1CC insulin syringe will be used for injection. Intervention 2: Intervention group 2: Group B will be treated with topical hydroquinone 4% every night. The duration of treatment will be 12 weeks, and the response will be evaluated every 4 weeks. No - There is not a plan to make this available Justification or reason for not sharing IPD is No decision has been made yet