IRCT20131017015044N4 IRCT 2020-01-23 Mashhad University of Medical Sciences Exploring the antitumor activity of curcumin in breast cancer Exploring the antitumor activity of curcumin in the treatment of breast-cancer patients 2019-12-22 anticipated 60 Complete https://irct.ir/trial/45148 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random allocation rule. This study with a sample size of 60 people, 30 balls for the placebo group and 30 balls for the intervention group are placed in a container and then the balls are randomly selected without replacement, Blinding description: sequentially numbered, sealed, opaque envelopes. A random sequence is created by random allocation rule. Then, based on the sample size, 60 envelopes with aluminum foil inside (to prevent ''hot lighting'') are prepared. Each entity in the random sequence is noted on a card and are replaced in numbered envelop. Finally, the envelopes are sealed and placed in boxes, respectively. The envelops are respectively assigned to each participant so the participant's assigned group is revealed. 3 Breast cancer. Intervention 1: Intervention group: Curcumin along with standard regime will be assigned to intervention group. The daily dose of crocin will be 80 mg during 24 weeks. Intervention 2: Control group: The treatment regimen is with CMF, CAF or AC-TAXAN and also placebo without Targeted therapy. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The research may be continued and the final results will be reported