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IRCT20160316027081N1 IRCT 2020-03-31 Artesh University of Medical Sciences Effect of Licorice in COVID-19 Comparison of the Effectiveness of Standard Treatment with Standard Treatment plus licorice extract as adjunctive treatment in Improving Respiratory Symptoms and Survival Rate in COVID-19 Patients 2020-03-23 anticipated 190 Complete https://irct.ir/trial/46678 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: In this study, we use a permuted four-block randomization method. For this purpose six blocks consisting of AABB, ABAB, ABBA, BBAA, BABA, and BAAB are designated and then for each of four patients, one of these blocks will be assigned using the random digit table. In fact, according to the order specified in each block, two patients will receive protocol A (standard treatment of COVID) and two patients will receive protocol B (standard treatment of COVID plus licorice extract). 2 COVID-19. Intervention 1: Intervention group: In this group of patients with COVID-19, in addition to standard treatment introduced by the Ministry of Health, the second drug is also prescribed. It is a licorice-based herbal extract that contains licorice, Rheum palmatum, Rosa damascene, Crocus sativus, and Ziziphus jujube. In order to prepare this extract, simple substances of these herbal are first prepared from the pharmaceutical market and after identification in the herbarium of the Faculty of Pharmacy of Tehran University of Medical Sciences, a herbarium code is assigned to each one. Then, a herbal syrup is extracted from these herbs by the maceration method. The syrup is standardized based on glycerol content, the total phenolic, and flavonoids compounds by HPLC method. Microbial controls are performed on the syrup. The syrup is packaged in 240 cc dark pets and given to the patient and at a dose of 10 cc every 8 hours for up to 8 days. Intervention 2: Control group: Patients in this group receive only standard treatment provided by the Ministry of Health for COVID-9. Yes - There is a plan to make this available What will be shared: Questionnaire When: After one year To whom: Deputy of research, Ministry of health Conditions: After formal request Where to obtain: AJA University of medical sciences, deputy of research How to obtain: From: Ministry of Health, Deputy of Research To: AJA University of Medical Sciences Comments: We are not permitted to publish the information of the military patients unprepared.
public Dr. Saeed Soleiman Meigooni
No 29, 1th Niloufar, Sarv Av, east Farsad, St, Javanmardan Bolv, Shahr-e-Ziba
Tehran Iran (Islamic Republic of) 1487784637 +98 21 4414 4939 dr.saeed.meigooni@gmail.com Artesh University of Medical Sciences scientific Dr. Saeed Soleiman-Meigooni
No 29, 1th Niloufar Alley, Sarv Av, east Farsad St, Javanmardan Blvd, Shahr e Ziba
Tehran Iran (Islamic Republic of) 1487784637 +98 21 4414 4939 Dr.saeed.meigooni@gmail.com Artesh University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) Admitted patients with COVID-19 in the four hospitals of AJA medical University in Tehran COVID-19 diagnosed by lung CT or naso-pharyngeal PCR 18 years no limit Both Severe hypersensitivity to the Licorice DKA or NKHC Pregnancy Decompensated Cirrhosis Non viral sepsis Active GIB Acute trauma or Surgical problem Unstable angina or Acute MI Chronic renal failure with Uremic symptoms U07.1 COVID-19, virus identified Treatment - Drugs Treatment - Drugs Intervention group: In this group of patients with COVID-19, in addition to standard treatment introduced by the Ministry of Health, the second drug is also prescribed. It is a licorice-based herbal extract that contains licorice, Rheum palmatum, Rosa damascene, Crocus sativus, and Ziziphus jujube. In order to prepare this extract, simple substances of these herbal are first prepared from the pharmaceutical market and after identification in the herbarium of the Faculty of Pharmacy of Tehran University of Medical Sciences, a herbarium code is assigned to each one. Then, a herbal syrup is extracted from these herbs by the maceration method. The syrup is standardized based on glycerol content, the total phenolic, and flavonoids compounds by HPLC method. Microbial controls are performed on the syrup. The syrup is packaged in 240 cc dark pets and given to the patient and at a dose of 10 cc every 8 hours for up to 8 days. Control group: Patients in this group receive only standard treatment provided by the Ministry of Health for COVID-9. Admission time. Timepoint: Daily. Method of measurement: Patients' profile (Yes or no). C-reactive protein. Timepoint: On admission, On discharge. Method of measurement: Laboratory test. Differences in lymphocyte count. Timepoint: on admission, on discharge. Method of measurement: with the cell counter device. The death number. Timepoint: at the end of admission. Method of measurement: base on the patient registries. Artesh University of Medical Sciences Approved 2020-03-18 Ethics committee of AJA University of Medical Sciences No 29, 1th Niloufar Ave, Sarv St, East Farsad St, avanmardan Blvd, Shahre Ziba Tehran Tehran Iran (Islamic Republic of)