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IRCT20200215046505N1 IRCT 2020-04-09 Shiraz University of Medical Sciences Effect of subgingival irrigation with Chamomile on periodontal disease Evaluation of the clinical effect of subgingival irrigation with chamomile, Persica and chlorhexidine on periodontal disease 2015-12-22 anticipated 11 Complete https://irct.ir/trial/46744 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: The participants on the research didnt know which irrigation material used,by white labels which hiding names of the viaاs containing. 3 periodontitis. Intervention 1: Intervention group:Immediately after scaling, each quadrant went under one of the subgingival irrigation with one of the mentioned materials, randomly. First groups material was Chammomile extract.We placed 40 grams of chamomile flower powder with herbarium code (PM 407) in a paper filter and was Soxhlet extractor (AshkeShishe Co., Iran) solved it in 1 liter of distilled water for 4 hours. 100 cc of it was freez- dried. At first the percent of dried material was calculated about 8 percent and then the liquid extract was used in the study. These process was repeated every week to make sure that the property was maintained. Irrigation was done by dull insulin syringes which were marked 2mm by a Williams probe. The syringe was placed 2mm under the gingival margin and the volume of the mouth rinse was proportionate to pocket depth as the liquid poured out the pocket. Suction was placed in the mouth in whole time of the irrigation. First irrigation was done immediately after the scaling and it was repeated two more times in 48-hour intervals. Patients were recommended not to eat or drink for two hours after the irrigation. The interval between the last teeth brushing and irrigation was considered at least 30 minutes. Intervention 2: Intervention group:Immediately after scaling, each quadrant went under one of the subgingival irrigation with one of the mentioned materials, randomly.Second group was chlorhexidine 0.2 % (Behsa Pharmaceutical Co., Iran).Irrigation was done by dull insulin syringes which were marked 2mm by a Williams probe. The syringe was placed 2mm under the gingival margin and the volume of the mouth rinse was proportionate to pocket depth as the liquid poured out the pocket. Suction was placed in the mouth in whole time of the irrigation. First irrigation was done immediately after the scaling and it was repeated two more times in 48-hour intervals. Patients were recommended not to eat or drink for two hours after the irrigation. The interval between the last teeth brushing and irrigation was considered at least 30 minutes. Intervention 3: Intervention group: Immediately after scaling, each quadrant went under one of the subgingival irrigation with one of the mentioned materials, randomly.Third group was persica (Poursina Pharmaceutical Co., Iran).Irrigation was done by dull insulin syringes which were marked 2mm by a Williams probe. The syringe was placed 2mm under the gingival margin and the volume of the mouth rinse was proportionate to pocket depth as the liquid poured out the pocket. Suction was placed in the mouth in whole time of the irrigation. First irrigation was done immediately after the scaling and it was repeated two more times in 48-hour intervals. Patients were recommended not to eat or drink for two hours after the irrigation. The interval between the last teeth brushing and irrigation was considered at least 30 minutes. Intervention 4: Control group: Immediately after scaling, each quadrant went under one of the subgingival irrigation with one of the mentioned materials, randomly.Third group was normal saline.Irrigation was done by dull insulin syringes which were marked 2mm by a Williams probe. The syringe was placed 2mm under the gingival margin and the volume of the mouth rinse was proportionate to pocket depth as the liquid poured out the pocket. Suction was placed in the mouth in whole time of the irrigation. First irrigation was done immediately after the scaling and it was repeated two more times in 48-hour intervals. Patients were recommended not to eat or drink for two hours after the irrigation. The interval between the last teeth brushing and irrigation was considered at least 30 minutes. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.
public Zahra Emami
Shiraz Dental School, Ghasrodasht Ave., Shiraz
Shiraz Iran (Islamic Republic of) 7195615878 +98 71 3626 3193 zahra_emami63@yahoo.com Shiraz University of Medical Sciences scientific Zahra Emami
Shiraz Dental School, Ghasrodasht Ave., Shiraz
Shiraz Iran (Islamic Republic of) 7195615878 +98 71 3626 3193 zahra_emami63@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Patients with moderate to severe chronic periodontitis which has over 3 millimeters attachment loss Having at least 20 teeth Existence of at least a pocket depth of 5 millimeters or more in posterior teeth in each quadrant Slow rate of disease progression without familial aggregation Without any history of systemic disease Volunteers whom was referred to periodontology department of Shiraz school of dentistry 30 years 70 years Both Any sub gingival crown or filling on the desired area History of allergy to chamomile Need for antibiotic prophylaxis History of any periodontal treatment and SRP in last 3 months Pregnancy Smokers Medical conditions which interfere with dental treatments K05.6 Periodontal disease, unspecified Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group:Immediately after scaling, each quadrant went under one of the subgingival irrigation with one of the mentioned materials, randomly. First groups material was Chammomile extract.We placed 40 grams of chamomile flower powder with herbarium code (PM 407) in a paper filter and was Soxhlet extractor (AshkeShishe Co., Iran) solved it in 1 liter of distilled water for 4 hours. 100 cc of it was freez- dried. At first the percent of dried material was calculated about 8 percent and then the liquid extract was used in the study. These process was repeated every week to make sure that the property was maintained. Irrigation was done by dull insulin syringes which were marked 2mm by a Williams probe. The syringe was placed 2mm under the gingival margin and the volume of the mouth rinse was proportionate to pocket depth as the liquid poured out the pocket. Suction was placed in the mouth in whole time of the irrigation. First irrigation was done immediately after the scaling and it was repeated two more times in 48-hour intervals. Patients were recommended not to eat or drink for two hours after the irrigation. The interval between the last teeth brushing and irrigation was considered at least 30 minutes. Intervention group:Immediately after scaling, each quadrant went under one of the subgingival irrigation with one of the mentioned materials, randomly.Second group was chlorhexidine 0.2 % (Behsa Pharmaceutical Co., Iran).Irrigation was done by dull insulin syringes which were marked 2mm by a Williams probe. The syringe was placed 2mm under the gingival margin and the volume of the mouth rinse was proportionate to pocket depth as the liquid poured out the pocket. Suction was placed in the mouth in whole time of the irrigation. First irrigation was done immediately after the scaling and it was repeated two more times in 48-hour intervals. Patients were recommended not to eat or drink for two hours after the irrigation. The interval between the last teeth brushing and irrigation was considered at least 30 minutes. Intervention group: Immediately after scaling, each quadrant went under one of the subgingival irrigation with one of the mentioned materials, randomly.Third group was persica (Poursina Pharmaceutical Co., Iran).Irrigation was done by dull insulin syringes which were marked 2mm by a Williams probe. The syringe was placed 2mm under the gingival margin and the volume of the mouth rinse was proportionate to pocket depth as the liquid poured out the pocket. Suction was placed in the mouth in whole time of the irrigation. First irrigation was done immediately after the scaling and it was repeated two more times in 48-hour intervals. Patients were recommended not to eat or drink for two hours after the irrigation. The interval between the last teeth brushing and irrigation was considered at least 30 minutes. Control group: Immediately after scaling, each quadrant went under one of the subgingival irrigation with one of the mentioned materials, randomly.Third group was normal saline.Irrigation was done by dull insulin syringes which were marked 2mm by a Williams probe. The syringe was placed 2mm under the gingival margin and the volume of the mouth rinse was proportionate to pocket depth as the liquid poured out the pocket. Suction was placed in the mouth in whole time of the irrigation. First irrigation was done immediately after the scaling and it was repeated two more times in 48-hour intervals. Patients were recommended not to eat or drink for two hours after the irrigation. The interval between the last teeth brushing and irrigation was considered at least 30 minutes. The rate of periodontal pocket depth. Timepoint: before intervention and 4 weeks after intervention. Method of measurement: periodontal probe. The rate of bleeding on probing. Timepoint: before intervention and 4 weeks after intervention. Method of measurement: periodontal probe. The rate of dental plaque. Timepoint: before intervention and 4 weeks after intervention. Method of measurement: Disclosing agent. Gingival recession rate. Timepoint: before intervention and 4 weeks after intervention. Method of measurement: periodontal probe. Mucogingival junction. Timepoint: before intervention and 4 weeks after intervention. Method of measurement: periodontal probe. Shiraz University of Medical Sciences Approved 2015-12-15 Ethics committee of Shiraz University of Medical Sciences Shiraz dental school, Ghasrodasht Ave., Shiraz Shiraz Fars Iran (Islamic Republic of)