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IRCT20180520039738N2 IRCT 2020-04-10 Saveh University of Medical Sciences Evaluation and comparison of the effectiveness of standard treatment with stand treatment plus Vitamin A in treatment in covid19 patients Comparison of the effectiveness of standard treatment with stand treatment plus Vitamin A in treatment in covid19 patients 2020-04-07 anticipated 140 Complete https://irct.ir/trial/46974 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: At the beginning of the study, an evaluator examines the criteria for entering the study of patients, and if there are conditions for entering the study, using the table of random numbers, patients will be assigned to the experimental and control group. And this process will continue until the formation of two equal groups of 70 people, Blinding description: In this study, patients, laboratory technicians, radiologists, and therapists who will be responsible for prescribing the drug, receiving the sample and completing the questionnaire, as well as the researcher responsible for evaluating the results and statistically analyzing the treatment group will blind patients. Were, and will not know the intervention group. The physicians responsible for prescribing medication will not be blind. vitamin A and placebo were purchased from the same factory and coded by the third person who is not involved in the study. the patients have received the random code by the secretariat who is not involved in the study. the patients with even numbers will receive the capsules from box A and the patients with odd numbers will receive the capsules from box B. To make a placebo, Since Zahrawi Vitamin A will be used for the experimental group, the control group will also use Zahrawi's placebo drug to make the placebo look and feel similar to the original vitamin A, but the active ingredient will be an ineffective substance. 3 Corona virus disease 2019 (COVID-19). Intervention 1: Intervention group:25000 IU vitamin A per day for ten days, the plus, the standard national treatment for COVID 19. Intervention 2: Control group: the standard national treatment for COVID19 ,and placebo. Yes - There is a plan to make this available What will be shared: By publishing an article When: Access started on September 2020 To whom: Researchers working in academic and scientific institutions Conditions: Scientific and therapeutic Where to obtain: Mohamad Reza Rohani, 00989122859099, mohamadreza.rohani@yahoo.com How to obtain: 72 hours after a phone call or email Comments:
public Mohammadreza Rouhani
No.4, Shahid Shiroodi St. - Alam Al-Huda St., Arak University of Medical Sciences, School of Medicine, Department of Internal Medicine
Arak Iran (Islamic Republic of) ٣٨١٩٦٩٣٣٤٥ +98 86 3368 4615 mohamadreza.rohani@yahoo.com Saveh University of Medical Sciences scientific Mohamadreza Rohani
Shahid Shiroodi St. - Alam Al-Huda St., Arak University of Medical Sciences, School of Medicine, Department of Internal Medicine
Arak Iran (Islamic Republic of) ٣٨١٩٦٩٣٣٤٥ +98 86 3368 4615 mohamadreza.rohani@yahoo.com Arak University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Covid 19 patients Age over one year Age less than 75 years Tendency to participate in research Completion of informed written consent 1 year 75 years Both pregnant women lactating women hepatitis B, C Autoimmune diseases Chronic renal failure (CRF) Liver failure Congestive heart failure (CHF) Chronic obstructive pulmonary disease (COPD) U07.1 COVID-19, virus identified Treatment - Other Treatment - Other Intervention group:25000 IU vitamin A per day for ten days, the plus, the standard national treatment for COVID 19 Control group: the standard national treatment for COVID19 ,and placebo Body temperature. Timepoint: before the start of the intervention and 10 days after the supplement Vitamin A. Method of measurement: Measureing body temperature with a thermometer through the mouth. Blood oxygen saturation percentage. Timepoint: Before and ten days after starting treatment. Method of measurement: Pulse oximeter. Cough rate. Timepoint: Before and ten days after starting treatment. Method of measurement: Physical examination. C-Reactive Protein (CRP) Test rate. Timepoint: Before and ten days after starting treatment. Method of measurement: Laboratory. Complete blood count (CBC) Rate. Timepoint: Before and ten days after starting treatment. Method of measurement: Laboratory. Creat. Rate. Timepoint: Before and ten days after starting treatment. Method of measurement: Laboratory. Lymphocytes Rate. Timepoint: Before and ten days after starting treatment. Method of measurement: Laboratory. Erythrocyte Sedimentation Rate (ESR) rate. Timepoint: Before and ten days after starting treatment. Method of measurement: Laboratory. Number of breaths. Timepoint: Before and ten days after starting treatment. Method of measurement: Physical examination. The pH of the blood. Timepoint: Before and ten days after starting treatment. Method of measurement: Laboratory. Creatine phosphokinase (CPK) rate. Timepoint: Before and ten days after starting treatment. Method of measurement: Laboratory. Lactate Dehydrogenase (LDH) rate. Timepoint: Before and ten days after starting treatment. Method of measurement: Laboratory. Liver function tests rate. Timepoint: Before and ten days after starting treatment. Method of measurement: Laboratory. Saveh University of Medical Sciences Approved 2020-04-03 Ethics committee of Saveh University of Medical Sciences Yas street, Kaveh industrial city, Saveh Saveh Markazi Iran (Islamic Republic of)