1) Objectives: As, physiological effects of eccentric exercise on the muscle performance has been shown in several studies in normal subjects, compared to concentric exercise, this study has been designed to investigate the special effect of these two type exercise in the patients with multiple sclerosis .
2) Design: Randomized clinical trial.
3) Setting and conduct: Concentric (walking on a treadmill with positive slope) and eccentric (walking on a treadmill with negative slope) exercise protocols were designed for experimental groups.
4) Participants including major eligibility criteria: 30 patients with multiple sclerosis will be participated according to the inclusion criteria including; ability to walk 10 meter in a less than 1 minute (with or without aim) and exclusion criteria including; sever decrease of functional ability during last year, Pregnancy, Corticosteroid treatment during last month, Sever Psychological condition, Any conditions cause to prevent mild or moderate sport activities, regular sport activity twice a week for more than 10 minutes in each session, simultaneously present another medical condition such as diabetic, lower limb arthritis, unstable cardiovascular conditions.
5) Intervention: The exercise protocol (concentric or eccentric exercise) included 30 minutes walking on treadmill within 55% of Maximum Heart rate which progressively increase to 85% Maximum Heart rate , for 12 sessions, 3 times a week.
6) Main outcome: a) Functional activity evaluations: including Two-Minute Walk، Timed 25 Foot Walk and Timed Get-up and Go, b) Static and dynamic balance indexes, c) Maximum isometric Torque of the left and right quadriceps and hamstring muscles, d) Disability and Ability index by completing Guy’s Neurological Disability Scale and Rivermead Mobility Index.