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IRCT20201115049393N1 IRCT 2021-01-30 Islamic Azad University The effect of combined training on ABCG4 gene expression and interleukin 4 and interleukin 10 factors in middle-aged men's blood mononuclear cells after coronary artery bypass graft CABG The effect of combined training on ABCG4 gene expression and interleukin 4 and interleukin 10 factors in middle-aged men's blood mononuclear cells after coronary artery bypass graft 2017-08-24 anticipated 26 Complete https://irct.ir/trial/52437 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: This project is part of a doctoral thesis that has been performed on patients with coronary artery bypass grafting and examines the effect of combined rehabilitation exercises on patients with coronary artery bypass grafting. 3 Patients with coronary artery bypass grafting. Intervention 1: Control group: Intervention group: 8 weeks of cardiac rehabilitation (aerobic training and resistance training) including 3 sessions per week with an intensity of 80-50% of the reserve heart rate or Borg standard 11-11 depending on the ability of the subjects and for each session up to 90 minutes The following: Walking on a treadmill for 20 to 30 minutes, cycling on a stationary bike for 10 to 12 minutes, using a manual ergo meter for 10 minutes, and resistance training include three repetitive sets, three movements for the upper limbs, and two lower limbs. The training course along with the usual treatment of risk factors for heart disease will include hyperglycemia and inflammation. Exercises will be performed in accordance with the principle of overload. Intervention 2: Control group: During this period, this group did not have any sports activities. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Due to the hospital's refusal to provide data, I am not able to provide data and information to other centers other than Neishabour Azad University.
public Dr. Amir Rashid Lamir
Hashemieh 14. Hashemieh Street
Mashhad Iran (Islamic Republic of) 9178613111 +98 51 3880 4840 amir.rashidlamir@gmail.com Islamic Azad University scientific Dr. Amir Rashid Lamir
Vakilabad Street, Ferdowsi University of Mashhad, Faculty of Sports Sciences
Mashhad Iran (Islamic Republic of) 9178613111 +98 51 3880 6000 amir.rashidlamir@gmail.com Islamic Azad University Iran (Islamic Republic of) 1. No systolic blood pressure higher than 160 mm Hg and diastolic blood pressure higher than 100 mm Hg 2. Cognitive, visual and auditory health 3. Do not use neuroleptics 4. Do not use walking aids such as canes and walkers 5. At least 2 months have passed since their operation 6. Their functional capacity should not be less than five met. Each met represents a consumption of 3.5 ml of oxygen per kilogram of body weight per minute, which was estimated based on a modified Bruce test 7. Age range 50 to 65 years 50 years 65 years Male Unstable angina, irreversible heart failure, myocardial infarction over the past four weeks, ventricular arrhythmias. Rehabilitation N/A Control group: Intervention group: 8 weeks of cardiac rehabilitation (aerobic training and resistance training) including 3 sessions per week with an intensity of 80-50% of the reserve heart rate or Borg standard 11-11 depending on the ability of the subjects and for each session up to 90 minutes The following: Walking on a treadmill for 20 to 30 minutes, cycling on a stationary bike for 10 to 12 minutes, using a manual ergo meter for 10 minutes, and resistance training include three repetitive sets, three movements for the upper limbs, and two lower limbs. The training course along with the usual treatment of risk factors for heart disease will include hyperglycemia and inflammation. Exercises will be performed in accordance with the principle of overload. Control group: During this period, this group did not have any sports activities ABCG4 gene expression and plasma levels of interleukin 4 and interleukin 10. Timepoint: 24 hours before the start of the protocol and 48 hours after the last training session. Method of measurement: Real-time-PCT gene expression and ELISA method. ABCG4 gene expression of interleukin 4 and interleukin 10. Timepoint: 24 hours before and 24 hours after the first and last training session. Method of measurement: Real-time-PCR method and ELISA method. Research Branch of neyshabour Azad University Approved 2017-04-23 National Committee of Ethics in Biomedical Research, Islamic Azad University. neyshabour unit Research Blvd., Islamic Azad University Complex, Neyshabur Branch Khorasan Razavi Province, Neyshabur Neyshabur Razavi Khorasan Iran (Islamic Republic of)