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IRCT20150711023153N2 IRCT 2021-02-28 Yasouj University of Medical Sciences Evaluation of the Effects of natural Pomegranate juice (Punica granatum) in patients with covid-19 Evaluation of the Effects of natural Pomegranate juice (Punica granatum) on CBC & inflammatory biomarkers in patients with covid-19: a Randomized clinical trial 2021-02-28 anticipated 48 Complete https://irct.ir/trial/53860 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Patients will be randomly divided into two groups of intervention or placebo by block random sampling method based on age (≥55 years or <55 years) and sex (male or female) in one of 8 blocks for 6 people, Blinding description: Blinding of patients, health care professionals, principal investigators as well as data collectors and data analysts will be unaware of the intervention and placebo groups at the end of the study. The intervention includes a placebo or natural pomegranate juice in special bottles and exactly same in color and taste are labeled with different numbers, and the contents of these numbers will be kept in a closed envelope in the faculty and its contents will be preserved until the end of the study. N/A Covid19. Intervention 1: Intervention group:Patients receiving 500 ml of natural pomegranate juice twice a day after lunch and after dinner + usual hospital medicine. Intervention 2: Placebo group: Patients receiving 500 ml placebo (water + food coloring approved by the Ministry of Health + 0.02% pomegranate emulsion according to the instructions) twice a day after lunch and after dinner + usual hospital medicine. Yes - There is a plan to make this available What will be shared: All potential data can be shared after blinding When: Six months after publishing To whom: Researchers working in academic institutions Conditions: For research purposes and meta-analysis studies Where to obtain: Dr. Seyed bahman panahande . Faculty member of the Health and Nutrition, Yasuj University of Medical Sciences How to obtain: Official letter to the researchers Comments:
public mojtaba yousefi
Imam Hossein Square - Golestan 15 School of Health and nutrition
yasuj Iran (Islamic Republic of) 7591875114 +98 74 3322 5519 mojtaba.yousefi@yums.ac.ir Yasouj University of Medical Sciences scientific seyed bahman panahande
Imam Hossein Square - Golestan 15 School of Health and nutrition
yasuj Iran (Islamic Republic of) 7591875114 +98 74 3322 5519 panahande.b@yums.ac.ir Yasouj University of Medical Sciences Iran (Islamic Republic of) Written informed consent form Age 18 years old or above COVID-19 diagnosis based on polymerase chain reaction (PCR) Acceptance for random assignment Willingness to participate in research study 18 years no limit Both Pregnancy or lactation IgA <61 mg/dl Disseminated intravascular coagulation or any other types of coagulopathy Severe congestive heart failure by the specialist Other contraindications prescribed by the specialist Participate in any clinical trial within the past 30 days prior to enrollment in the present study U07.1 U07.1 Treatment - Other Placebo Intervention group:Patients receiving 500 ml of natural pomegranate juice twice a day after lunch and after dinner + usual hospital medicine Placebo group: Patients receiving 500 ml placebo (water + food coloring approved by the Ministry of Health + 0.02% pomegranate emulsion according to the instructions) twice a day after lunch and after dinner + usual hospital medicine Interleukin 6. Timepoint: Before the intervention and at the end of day 14 of the study. Method of measurement: Elisa Kit. CRP. Timepoint: Before the intervention and at the end of day 14 study. Method of measurement: Elisa Kit. Erythrocyte Sedimentation Rate (ESR). Timepoint: Before the intervention and at the end of day 14 of the study. Method of measurement: Elisa Kit. CBC. Timepoint: Before the intervention and at the end of day 14 of the study. Method of measurement: Elisa Kit. Yasouj University of Medical Sciences Approved 2021-01-20 Ethics Committee of Yasuj University of Medical Sciences Yasuj-Shahid Motahari Boulevard-Yasuj University of Medical Sciences Yasuj Kohgilouyeh-va-Boyrahmad Iran (Islamic Republic of)