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IRCT20190618043934N9 IRCT 2021-04-14 Birjand University of Medical Sciences The effect of azithromycin 1 on the signs and symptoms of blepharitis The effect of a 1% azithromycin eye drops treatment on signs and symptoms of blepharitis 2021-04-21 anticipated 45 Complete https://irct.ir/trial/55214 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Participants in the study will be randomly divided into two intervention groups receiving azithromycin 1% (group A) and the control group receiving erythromycin (group B) by simple blocking method. Patients with the above conditions in two groups are randomly entered into one of the two intervention or control groups by blocking method (quadruple blocks). Thus, various quadrilateral blocks were created (AABB, BBAA, ABAB, BABA, ABBA and BABA). One of these blocks will be randomly selected and patients will be divided into one of two groups A or B. Then randomization was performed for other patients, Blinding description: Outcome Assessor: The ward nurse, without knowing the type of medication received, questions the patients and records them in the relevant checklist. Participants in the study without knowing the medication received for the treatment of blepharitis, which is the gold standard treatment or the new treatment for blepharitis. 3 Blepharitis. Intervention 1: Intervention group: Patients receiving azithromycin 1% eye drops (manufactured by Sina Daru Pharmaceutical Company-Iran) topically twice a day for 4 days. Intervention 2: Control group: Patients receiving topical erythromycin eye ointment (manufactured by Iran Najo_Iran Pharmaceutical Company) 2 times a day for 4 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no need to publish individual patient information
public Zabihullah Mohaghegh
Ghaffari Blvd
Birjand Iran (Islamic Republic of) 9717934888 +98 56 3232 3232 oabstudent@gmail.com Birjand University of Medical Sciences scientific Dr. Seyed Abase Hoseinirad
Ghaffari Blvd
Birjand Iran (Islamic Republic of) 9717811674 +98 56 3232 3232 oabstudent@gmail.com Birjand University of Medical Sciences Iran (Islamic Republic of) Patients with anterior blepharitis Age 18 to 80 years 18 years 80 years Both Eye injuries and infections Non-dry eye inflammation, surgery Eye trauma in the last 6 months H01.0 Blepharitis Treatment - Drugs Treatment - Drugs Intervention group: Patients receiving azithromycin 1% eye drops (manufactured by Sina Daru Pharmaceutical Company-Iran) topically twice a day for 4 days. Control group: Patients receiving topical erythromycin eye ointment (manufactured by Iran Najo_Iran Pharmaceutical Company) 2 times a day for 4 days. Clinical signs and symptoms of blepharitis include eye irritation, itching and burning of the eyelids, eye discomfort after working with a computer, a feeling of heaviness in the eyelids, discharge on the eyelashes, a feeling of dry eyes, sticking of the eyelids when waking up and redness of the eyes. Timepoint: Before and after the intervention (4 weeks after the intervention). Method of measurement: Self-reported using the standard OcularSurfaceDiseaseIndex questionnaire. Birjand University of Medical Sciences Approved 2021-03-01 Ethics Committee of Birjand University of Medical Sciences Ghaffari Blvd Birjand South Khorasan Iran (Islamic Republic of)