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IRCT20210424051061N1 IRCT 2021-09-29 Gonabad University of Medical Sciences Effect of continuous and biphasic positive airway pressure in patients with Covid cbpapc Comparison of the effect of continuous positive airway pressure )CPAP) and biphasic Positive Airway Pressure (BiPAP) on hemodynamic parameters in covid-19 patients 2021-05-05 anticipated 46 Complete https://irct.ir/trial/55790 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: -, Randomization description: In this study, first, individuals are entered into the study in an accessible manner based on inclusion and exclusion criteria, and then using permutation blocks in two groups, CPAP mask and BIPAP mask will be allocated. In this method, if we consider the cpap group A, the bipap group B, the 6 possible states will be in the 4 blocks AABB-BBAA-ABAB-BABA-BAAB-ABBA, which will be assigned a number for each block and each The load will be selected by lot and patients will enter the study, respectively, Blinding description: In this study, participants, health care personnel (physicians, nurses, physiotherapists, etc.) who are responsible for patient care, used the allocation of the device and did not know the purpose of the study. 2-3 Covid-19. Intervention 1: Intervention group: In this research, the CPAP device of Saadat and venet manufacturers is used. Using an air pump, the CPAP device transmits airflow to the patient at a pressure set by the mask. The device settings are adjusted by a physician or specialist based on the information contained in the sleep test. These settings include parameters such as the number of apneas; Adjustable pressure range: 20 - 4 cm water; Pressure adjustment: 3 - 0 cm of water; Adjustable initial pressure by the patient; Device settings with buttons; LED lights on the device; Storing, calculating and retrieving information is like the average total treatment hours. Intervention 2: Intervention group: In this research, the BIPAP device of Fisher and Resmed manufacturers is used, which includes a humidifier chamber-hose and mask whose settings include IPAP-EPAP (IPAP applies maximum pressure at the time of inhalation and EPAP minimum pressure at the time of Exhale). Yes - There is a plan to make this available What will be shared: All data is potentially shareable after unidentified individuals When: After completing the plan To whom: Only for researchers working in academic and scientific institutions Conditions: For research Where to obtain: Researcher email address How to obtain: Researcher email address Comments:
public Dr. Kokab Basiri Moghaddam
9P67+R29,Imam Khomeini street, Gonabad, Razavi Khorasan Province
Gonabad Iran (Islamic Republic of) 5722351322 +98 51 5722 3513 k.basiri@gmu.ac.ir Gonabad University of Medical Sciences scientific Dr. Kokab Basiri Moghaddam
9P67+R29, Gonabad, Imam Khomeini street, Razavi Khorasan Province
Gonabad Iran (Islamic Republic of) 5722351322 +98 51 5722 3513 k.basiri@gmu.ac.ir Gonabad University of Medical Sciences Iran (Islamic Republic of) Willingness to participate in the study Age 20 -60 y/o No history of cardiovascular disease such as hypertension, liver, kidney according to self-declaration Need to prescribe oxygen and candidate for non-invasive respiratory assistance (NIV) according to physician (no need for intubation) No ban on the use of masks Definitive diagnosis of coronavirus infection by physician and laboratory results 20 years 60 years Both Need to intubate the patient immediately Awareness level based on the Glasgow scale less than 15 Any change in the patient's condition that affects the course of treatment, for example blood pressure below 90 mmhg despite fluid therapy or the use of vasopressors B34.2 Coronavirus infection, unspecified Treatment - Drugs Treatment - Drugs Intervention group: In this research, the CPAP device of Saadat and venet manufacturers is used. Using an air pump, the CPAP device transmits airflow to the patient at a pressure set by the mask. The device settings are adjusted by a physician or specialist based on the information contained in the sleep test. These settings include parameters such as the number of apneas; Adjustable pressure range: 20 - 4 cm water; Pressure adjustment: 3 - 0 cm of water; Adjustable initial pressure by the patient; Device settings with buttons; LED lights on the device; Storing, calculating and retrieving information is like the average total treatment hours. Intervention group: In this research, the BIPAP device of Fisher and Resmed manufacturers is used, which includes a humidifier chamber-hose and mask whose settings include IPAP-EPAP (IPAP applies maximum pressure at the time of inhalation and EPAP minimum pressure at the time of Exhale). Mean score of hemodynamic parameters. Timepoint: Before the mask is prescribed, it will be examined by a person immediately after use and after 1 hour, 6 hours and then daily for up to 3 days at a specific time. Method of measurement: Patient-connected monitoring device. Mean oxygen saturation, mean blood pressure, mean pulse rate. Timepoint: Based on the monitor attached to the patient before the mask is administered, immediately after use and after 1 hour, 6 hours and then daily for up to 3 days at a specific time will be examined by one person. Method of measurement: Patient-connected monitoring device. Vice Chancellor for Research, Gonabad University of Medical Sciences Gonabad University of Medical Sciences Vice Chancellor for Research, Gonabad University of Medical Sciences Approved 2021-04-21 Ethics committee of gonabad University of Medical Sciences 9P67+R29,Imam Khomeini street, Gonabad, Razavi Khorasan Province Gonabad Razavi Khorasan Iran (Islamic Republic of)