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IRCT20141209020258N160 IRCT 2021-06-06 Vice chancellor for research, Arak University Of Medical Sciences Comparison of the effect of vitamin C and N-acetyl cysteine (NAC) on improving clinical symptoms and reducing the duration of hospitalization in patients with covid-19 Comparison of the effect of vitamin C and N-acetyl cysteine (NAC) on improving clinical symptoms and reducing the duration of hospitalization in patients with covid-19 2021-06-15 anticipated 232 Complete https://irct.ir/trial/56545 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple individual randomization with random allocation with envelopes in 2 groups A and B . In this method, we selected a number of cards or letters as an intervention group and the same ‎number of cards for the control group, then the cards were merged. One card was taken out and its ‎allocation was registered and the card was returned to the other cards after leaving. Then the cards ‎are merged again and we remove another card. This process continues to reach a random sequence ‎according to sample size, Blinding description: This study is a double-blind clinical trial. In this study, patients consciously consented to take vitamin C and N-acetylcysteine supplements but did not know the type of group they were entering. The drug is prescribed by infectious and internal medicine physicians in charge of the project and is randomly given to one of these two groups; However, the intern in charge of the project, who is responsible for registering questionnaires and collecting data, also does not know about the patient group. 3 Covid-19. Intervention 1: Intervention group 1: Vitamin C tablets with a dose of 1 gram are given every 8 hours for 5 days. Intervention 2: Intervention group 2: N-acetylcysteine tablets at a dose of 600 mg every 8 hours for 5 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Dr Behnam Mahmodie
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 mahmodie@arakmu.ac.ir Arak University of Medical Sciences scientific Dr Alireza Kamali
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 68 3222 2003 alikamaliir@yahoo.com Arak University of Medical Sciences Iran (Islamic Republic of) Age over 18 years No pregnancy or breastfeeding Absence of G6PD deficiency No history of calcium oxalate kidney stones Lack of sensitivity to drugs 18 years no limit Both Dissatisfaction U07.1 COVID-19, virus identified Treatment - Drugs Treatment - Drugs Intervention group 1: Vitamin C tablets with a dose of 1 gram are given every 8 hours for 5 days. Intervention group 2: N-acetylcysteine tablets at a dose of 600 mg every 8 hours for 5 days. Percentage of oxygen saturation. Timepoint: During the intervention. Method of measurement: Pulse oximetry. Duration of hospitalization in the intensive care unit. Timepoint: During the intervention. Method of measurement: Observation. Vice chancellor for research, Arak University Of Medical Sciences Approved 2021-05-09 Ethics comittee of Arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)