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IRCT20210504051178N1 IRCT 2022-02-05 Iran National Science Foundation Effect of mechanichal stimulation on parkinsonian tremor and Essential tremor Effect of skin mechanoreceptors stimulation on resting tremor in parkinsonian patients and kinetic tremor in patients with essential tremor. 2022-02-05 anticipated 15 Complete https://irct.ir/trial/60423 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: Parkinson 'patients are selected , examined and grouped randomized by neurology resident. Intervention of each group is doing by biomedical engineering phd student. Neurology resident does examination of groups and gathers information but intervention of groups is unknown. Analysis of data is doing by phd student while the identity of data is not evident. N/A Condition 1: Parkinson's disease. Condition 2: Essential tremor. Intervention 1: Intervention group 1: 5 parkinson' patients will be intervened on the hand while it is at a rest position , consecutive 10 session for half an hour duration is designed. Tremor severity will be evaluate based on UDPRS criteria and accelerometer at first and final session and one month later. Intervention 2: Intervention group 2: 5 Essential tremor' patients will be intervened on the hand while it is drawing a figure , consecutive 10 session for half an hour duration is designed. Tremor severity will be evaluate based on TETRAS criteria and accelerometer at first and final session and one month later. Intervention 3: Control group: We put equipment on the hand of 5 parkinson' patients at a rest position, consecutive 10 session for half an hour duration is designed. Tremor severity will be evaluate based on UDPRS criteria and accelerometer at first and final session and one month later. Yes - There is a plan to make this available What will be shared: some part of data can be communalized When: 6 months after publication To whom: researchers of scientific institution and university Conditions: different analysis for researchers Where to obtain: Ali Shoeibi MD, Ahmad Abad Blvd, Qaem hospital, shoeibia@mums.ac.ir How to obtain: emailing, duration:3 weeks Comments:
public Ali Shoeibi
Ghaem Hospital
Mashhad Iran (Islamic Republic of) 9187145785 +98 51 3840 0000 shoeibia@mums.ac.ir Mashhad University of Medical Sciences scientific Ali Shoeibi
Ghaem Hospital
Mashhad Iran (Islamic Republic of) 9187145785 +98 51 3840 0000 shoeibia@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Parkinson disease is diagnosed based on MDS criteria At least one hand has rest tremor 40 years old at the onset of disease. All patients will fill out a consent form Kinetic tremor in hand ( Essential tremor) 40 years no limit Both Severe disabilities Neuropathy MMSE score less than 26 Mood disorders and anxiety treatment with DBS and apomorphine pump Dose of drugs changed one month before Accompany of disorders or drugs that exaggerated tremor G20 G25.0 Parkinson's disease Essential tremor Treatment - Devices Treatment - Devices Placebo Intervention group 1: 5 parkinson' patients will be intervened on the hand while it is at a rest position , consecutive 10 session for half an hour duration is designed. Tremor severity will be evaluate based on UDPRS criteria and accelerometer at first and final session and one month later. Intervention group 2: 5 Essential tremor' patients will be intervened on the hand while it is drawing a figure , consecutive 10 session for half an hour duration is designed. Tremor severity will be evaluate based on TETRAS criteria and accelerometer at first and final session and one month later. Control group: We put equipment on the hand of 5 parkinson' patients at a rest position, consecutive 10 session for half an hour duration is designed. Tremor severity will be evaluate based on UDPRS criteria and accelerometer at first and final session and one month later. Tremor severity. Timepoint: before beginning of intervention ( at the first of sampling and start of intervention), final session, after one month. Method of measurement: part 3 of UDPRS criteria (The Unified Parkinson's Disease Rating Scale) and accelerometer, TETRAS scoring for Essential tremor. Iran National Science Foundation Approved 2021-01-19 Ethics committee of mashhad university of medical sciences No 11. Goldis Ave, Boronsi Blvd, mashhad city Mashhad Razavi Khorasan Iran (Islamic Republic of)