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IRCT20211230053569N1 IRCT 2023-04-11 Riphah International University Anesthetic efficacy of articaine with lidocaine in symptomatic irreversible pulpitis Comparison of anesthetic efficacy of articaine with lidocaine as an inferior nerve blocking agent in subjects with symptomatic irreversible pulpitis 2022-08-01 anticipated 152 Complete https://irct.ir/trial/61076 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Before the experiment, each of the two anesthetic solutions will be labeled as A and B. Simple, individual randomization will be done and subjects will be randomly allocated either solution A or B, using online randomization software (OpenEpi), Blinding description: Before the experiment, each of the two anesthetic solutions will be covered to conceal the name of the product and labeled as A and B respectively. Both the chief researcher and the patient will be unaware of which alphabet represents which solution. 1-2 Symptomatic irreversible pulpitis in posterior mandibular teeth. Intervention 1: Intervention group: subjects diagnosed with symptomatic irreversible pulpitis (after taking history, carrying out cold testing and filling the Visual Analogue Scale to score pain levels) receiving 1.7 ml of 4% articaine with 1:100,000 epinephrine (Septanest SP) as inferior nerve blocking agent. Intervention 2: Control group: subjects diagnosed with symptomatic irreversible pulpitis (after taking history, carrying out cold testing and filling the Visual Analogue Scale to score pain levels) receiving 1.7 ml of 2% lidocaine with 1:100,000 epinephrine (Lignospan standard), as inferior nerve blocking agent. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Subject to willingness of the participants of the study
public Dr Sobia Hassan
Street 41A, 7th Avenue, G-7/4
Islamabad Pakistan 44000 +92 51 2891835 sobia.hassan@riphah.edu.pk Riphah International University scientific Dr Sobia Hassan
Street 41A, 7th Avenue, G-7/4
Islamabad Pakistan 44000 +92 51 2891835 sobia.hassan@riphah.edu.pk Riphah International University Pakistan Subjects of both genders (males and females), in good health, with no systemic disease that will interfere with the action of any of the anesthetic solutions being used, aged between 26 – 35 years Mandibular posterior teeth requiring endodontic treatment due to symptomatic irreversible pulpitis There should have been no previous attempts of endodontic therapy on that tooth Positive pulp sensibility testing (cold testing) 26 years 35 years Both Patients who have known allergy to amides Patients taking any medication that will alter their perception of pain Patients who are suffering from any heart disease, diabetes mellitus Female patients who are pregnant K04.02 Irreversible pulpitis Treatment - Drugs Treatment - Drugs Intervention group: subjects diagnosed with symptomatic irreversible pulpitis (after taking history, carrying out cold testing and filling the Visual Analogue Scale to score pain levels) receiving 1.7 ml of 4% articaine with 1:100,000 epinephrine (Septanest SP) as inferior nerve blocking agent. Control group: subjects diagnosed with symptomatic irreversible pulpitis (after taking history, carrying out cold testing and filling the Visual Analogue Scale to score pain levels) receiving 1.7 ml of 2% lidocaine with 1:100,000 epinephrine (Lignospan standard), as inferior nerve blocking agent. Pain relief after anesthesia. Timepoint: Immediately after intervention. Method of measurement: Visual Analogue Scale for pain assessment. Riphah International University Approved 2020-01-01 Ethics Committee of Islamic International Dental College Street 41, off 7th Avenue, G-7/4 Islamabad ICT Pakistan