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IRCT20220115053712N1 IRCT 2022-02-02 Muhammad Institute of Medical and Allied Sciences, Multan Comparative analysis of Topical Glucosamine Sulfate and Proprioceptive Exercises on Pain and Functional Disability in Knee Osteoarthritis GS,OA Comparative analysis of Topical Glucosamine Sulfate and Proprioceptive Exercises on Pain and Functional Disability in Knee Osteoarthritis 2021-11-15 anticipated 38 Complete https://irct.ir/trial/61283 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Patients were assessed by radiological finding (x-ray) and by physical assessment, Randomization description: Allocation concealment occurs and patients will be recruited by using simple randomization through the Lottery method. lottery method carried out through sealed envelopes. Each participant will randomly choose the sealed envelope and open this sealed envelope, Blinding description: In a single-blinded study, participants will be blinded. Participants will be unaware of the type of treatments that will be evaluated after the completion of the intervention trial. subjects will choose between two samples. both the samples are in the same packing. In one sample, glucosamine sulfate gel with conventional exercises i.e., ankle pumps, quadriceps isometrics, and calf stretch. In another sample, an aqueous gel with no effects for the satisfaction of subjects and proprioceptive exercises will be given. Subjects will be completely unaware of the type and effects of both interventions. 4 Knee Osteoarthritis with grade 1, 2 and 3. Intervention 1: intervention group 2; group-B will be treated with proprioceptive exercises. The proprioceptive exercises are Standing on 1 leg [eyes open and closed], Knee flexion and extension exercises (sitting position with a chair and TheraBand [Akron, OH]), Walking on heel and toes (forward, backward, left, right, carioca crossover with eyes open and closed). Half squat on soft ground, Side lunge, One-legged balance exercise. The duration of treatment is 6 weeks. The frequency of treatment is 3 times per week exercise sessions lasted 30 minutes. Intervention 2: Intervention group: Group-A will be treated with topical glucosamine sulfate, ankle pumps, quads strengthening, and calf stretching. The drug will purchase from stand pharmaceuticals. The duration of treatment is 6 weeks. Glucosamine sulfate will apply topically twice daily, 3 times per week. The dosage of glucosamine sulfate gel will be 250mg two times a day. Subjects will be instructed to clean the skin adjacent to their throbbing knee and apply the cream. Yes - There is a plan to make this available What will be shared: Title of my study comparative analysis of Topical Glucosamine Sulfate and Proprioceptive Exercises on Pain and Functional Disability in Knee Osteoarthritis. The basic purpose of this research is to compare the effects of Proprioceptive exercises and glucosamine sulfate on knee osteoarthritis. The expected outcome of this study is proprioceptive exercises may be more effective than glucosamine sulfate. Proprioceptive exercise may improve ADLs and reduce pain. A randomized clinical trial was conducted at Muhammad physical therapy clinic and rehabilitation center, Multan and Faiz Hospital, Multan. 30 patients were selected who met the inclusion criteria will be randomized into two groups; treatment group (A) and treatment group (B). patients were recruited by using the lottery method. Group (B) will be treated with proprioceptive exercises and group (A) will be treated with glucosamine sulfate. When: This is expected that this study or data will be available at the end of this year 2022. No exact date can be expected. To whom: Nimra Arif Conditions: For research purposes Where to obtain: researchgate.net https://scholar.google.com/ hifzaa630@gmail.com How to obtain: open access Comments: I want randomized clinical trial registration. please provide me as soon as possible. so that I can continue my study
public Dr.Zahid Manzoor
HBL street, near Sabzazar metro station, Bosan road Multan, Pakistan
Multan Pakistan 60700 +92 309 7697428 drhifzaarif@mimas.edu.pk Muhammad Institute of Medical and Allied Sciences, Multan, Pakistan scientific Nimra Arif
HBL street, sbzazar station, Bosan road, Multan, Pakistan
Multan Pakistan 60700 +92 333 3877032 angelnimra95@gmail.com Muhammad Institute of Medical and Allied Sciences, Multan, Pakistan Pakistan Pakistan bilateral knee OA with grade 1,2 and 3 Age 45-70 years Both genders (male and female) Cartilage degeneration Local biomechanical factors (e.g., obesity, joint deformity, muscle weakness) Nutritional factors Postmenopausal women 45 years 70 years Both Rheumatoid arthritis Neurological disorders (e.g., Alzheimer’s disease, Parkinson’s disease) Knee replacement Steroidal injection in the past 2 months Neuropathy Tumor Knee fractures Knee OA with grade 4 M17 Osteoarthritis of knee Treatment - Other Treatment - Drugs intervention group 2; group-B will be treated with proprioceptive exercises. The proprioceptive exercises are Standing on 1 leg [eyes open and closed], Knee flexion and extension exercises (sitting position with a chair and TheraBand [Akron, OH]), Walking on heel and toes (forward, backward, left, right, carioca crossover with eyes open and closed). Half squat on soft ground, Side lunge, One-legged balance exercise. The duration of treatment is 6 weeks. The frequency of treatment is 3 times per week exercise sessions lasted 30 minutes. Intervention group: Group-A will be treated with topical glucosamine sulfate, ankle pumps, quads strengthening, and calf stretching. The drug will purchase from stand pharmaceuticals. The duration of treatment is 6 weeks. Glucosamine sulfate will apply topically twice daily, 3 times per week. The dosage of glucosamine sulfate gel will be 250mg two times a day. Subjects will be instructed to clean the skin adjacent to their throbbing knee and apply the cream Pain and functional disability. Timepoint: before and after treatment (6 weeks). Method of measurement: Numerical Pain Rating Scale (NPRS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC). To reduce stiffness, muscle tone strength increases and joint receptor function raised. Timepoint: before and after treatment(6 weeks). Method of measurement: Numerical Pain Rating Scale (NPRS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC). Muhammad Institute of Medical and Allied Sciences, Multan Approved 2021-09-18 The Institutional Ethical Committee of Muhammad Institute of Medical and Allied Sciences, Multan st HBL street, Sbzazar metro station, Bosan road, Multan, Pakistan Multan Punjab Pakistan