IRCT20220115053712N2 IRCT 2022-02-28 Muhammad Institute of Medical and Allied Sciences, Multan Proprioceptive Exercises with and without Topical Glucosamine Sulfate in Knee Osteoarthritis Comparative analysis of Proprioceptive Exercises with and without Topical Glucosamine Sulfate on Pain and Functional Disability in Knee Osteoarthritis 2021-12-15 anticipated 39 Complete https://irct.ir/trial/61682 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: participants will be assessed by physical assessment and by radiological findings (x-ray), Randomization description: Allocation concealment occurs and patients will be recruited by using simple randomization through the Lottery method. lottery method carried out through sealed envelopes. Each participant will randomly choose the sealed envelope and open this sealed envelope, Blinding description: In a double-blinded study, participants and investigators will be blinded. Participants will be unaware of the type of treatments that will receive and the investigator will be unaware of the type of treatment on which group which intervention will be given and for what purpose that be evaluated after the completion of the intervention trial. subjects will choose between two samples. both the samples are in the same packing. In one sample, glucosamine sulfate gel with proprioceptive exercises i.e., standing on 1 leg [eyes open and closed], knee flexion and extension exercises [sitting position with a chair and TheraBand], Walking on heel and toes [forward, backward, left, right, carioca crossover with eyes open and closed], Half squat on soft ground, Side lunge, One-legged balance exercise. In another sample, an aqueous gel with no effects for the satisfaction of subjects and proprioceptive exercises i.e., Standing on 1 leg [eyes open and closed], Knee flexion and extension exercises [sitting position with a chair and TheraBand], Walking on heel and toes [forward, backward, left, right, carioca crossover with eyes open and closed], Half squat on soft ground, Side lunge, One-legged balance exercise will be given. Subjects and investigators will be completely unaware of the type and effects of both interventions. 2 Knee Osteoarthritis with grades 1, 2 and 3. Intervention 1: Control group: Group A will be treated with only proprioceptive exercises. The proprioceptive exercises are Standing on 1 leg [eyes open and closed], Knee flexion and extension exercises (sitting position with a chair and TheraBand ), Walking on heel and toes (forward, backward, left, right, carioca crossover with eyes open and closed). Half squat on soft ground, Side lunge, One-legged balance exercise. The duration of treatment is 6 weeks. The frequency of treatment is 3 times per week exercise sessions lasted 30 minutes. Intervention 2: treatment group: Group-B will be treated with proprioceptive exercises and glucosamine sulfate. The proprioceptive exercises are Standing on 1 leg [eyes open and closed], Knee flexion and extension exercises (sitting position with a chair and TheraBand ), Walking on heel and toes (forward, backward, left, right, carioca crossover with eyes open and closed). Half squat on soft ground, Side lunge, One-legged balance exercise. The duration of exercise is 6 weeks. The frequency of exercise is 3 times per week exercise sessions lasted 30 minutes. The glucosamine sulfate will apply topically twice daily, 3 times per week. the dosage of glucosamine sulfate gel will be 250mg two times a day. subjects will be instructed to clean the skin adjacent to their throbbing knee and apply the cream. Yes - There is a plan to make this available What will be shared: Demographic data and data related to final outcome will be shared by maintaining the confidentiality When: data will be available from Feb 2023 to March 2023 after the 6 months of publication. The data sharing plan for a clinical trial (i.e., what data will be shared when and under what conditions) will be publicly available at a third-party site that shares data with and meets the data requirements of WHO's International Clinical Trials Registry Platform; this occur before the first participant is enrolled. To whom: Hifza Arif(corresponding author) Senior lecturer at Ali-Ul-Murtaza Department of Rehabilitation Sciences and Muhammad Institute of Medical and Allied Sciences Multan, Pakistan Conditions: For research purposes Where to obtain: To the corresponding author of the study; Dr. Hifza Arif and can contact on +923097697428 hifzaa630@gmail.com can visit these search engines, you can find my study easily here https://www.researchgate.net/ https://scholar.google.com/ How to obtain: open-access and There is the traditional public data release where anyone can get access to the data with no registration or conditions. The request will be reviewed by Director in Charge and in case of eligibility, it would be shared in two weeks. Comments: I want randomized controlled trial registration.