IRCT20220517054899N1 IRCT 2022-08-13 Birjand University of Medical Sciences The effect of Plasmapheresis on hypoxia in patients suffering from COVID-19 BPS The effect ofPlasmapheresis on hypoxia in patients suffering from COVID-19: A randomized clinical trial 2022-07-22 anticipated 40 Complete https://irct.ir/trial/64354 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization based on the table of random numbers. A set of numbers without a specific pattern and order and in a completely random manner are in the form of a table. The direction of reading the numbers in this table will be from top to bottom and right to left. Even numbers will be considered for the intervention group and odd numbers for the control group. 3 Corona virus (Covid-19). Intervention 1: Intervention group: Patients in the intervention group, in addition to the standard treatment of Covid-19, (dexamethasone at a dose of 6 mg per day and remedSivir at a dose of 200 mg on the first day and then 100 mg daily for 7 days) will undergo the intervention (plasmapheresis). Each time plasmapheresis is performed, 40 ml per kg of body weight of the patient's plasma is replaced with 5% human albumin and 0.9% normal saline, and for each patient, if the clinical symptoms do not improve, plasmapheresis will be performed up to 3 times. Intervention 2: Control group: In this group, patients received the standard treatment of Covid-19 according to the national protocol (Hedhexamethasone 6 mg daily and Ramdesiver 200 mg on the first day and 100 mg daily for 7 days). Yes - There is a plan to make this available What will be shared: - When: - To whom: - Conditions: - Where to obtain: - How to obtain: - Comments: -