<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT20210704051785N2</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2022-09-26</date_registration>
      <primary_sponsor>sharif medical and dental college</primary_sponsor>
      <public_title>which exercise can reduce blood pressure, sugar and joint pain</public_title>
      <acronym>RCT</acronym>
      <scientific_title>Effects of Resistance Training Versus Endurance Training on Hyperlipidemia, Uric Acid and Glucose levels In Patients with Metabolic Syndrome: a randomized clinical trial</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2022-09-01</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>64</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/66023</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: no, Randomization description: Sealed envelope method will be used for random allocation. 64 sealed envelopes (32 for Group A and 32 for Group B) will be prepared. 32 envelopes will contain letter A, 32 envelopes will contain letter B on a card. Patient will be asked to choose one envelope. Treatment will be given according to treatment group (Group A: control, Group B: experiment), Blinding description: Senior physiotherapist will assess patient before and after treatment. Senior physiotherapist/assessor will be completely blinded about patient allocation group (control/intervention).</study_design>
      <phase>N/A</phase>
      <hc_freetext>Condition 1: metabolic syndrome. Condition 2: hyperlipidemia. Condition 3: diabetes.</hc_freetext>
      <i_freetext>Intervention 1: Intervention group: follows Resistance exercises( 6 days a week ): exercise starts with 30% repetition maximum of resistance exercise training on multiple exercise units, 3 sets of 9 exercises, six times per week with 10 repetitions, 1 min rest between sets. The load will be adjusted every month according to the 70% 1RM rule.9 resistance exercises that will be followed during 12 weeks on multiple exercise units are listed below1.	Front raises2.	Shoulder shrug3.	Bicep curl4.	Seated dumbbell press5.	Lateral raises6.	Pull down7.	Leg extension curl8.	Seated row9.	Chest press23. Intervention 2: control group: Endurance exercises: 30 min per day( 6 days a week ) of endurance exercise training on the treadmill, intensity will be adjusted through HRmax.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan>Undecided - It is not yet known if there will be a plan to make this available</results_IPD_plan>
      <results_IPD_description>Justification or reason for indecision in sharing IPD is there is no further information</results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Fozia Butt</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Sharif polyclinic, near doce bakers, railway road raiwind, Sharif polyclinic</address>
        <city>Lahore</city>
        <country1>Pakistan</country1>
        <zip>55150</zip>
        <telephone>+92 42 86586523</telephone>
        <email>sarwatasifmehmood@gmail.com</email>
        <affiliation>Sharif Medical and Dental College</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Sarwat Anees</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Sharif Polyclinic, near Doce Bakers, Railway Road, Raiwind</address>
        <city>Lahore</city>
        <country1>Pakistan</country1>
        <zip>55150</zip>
        <telephone>+92 303 4846498</telephone>
        <email>sarwatasifmehmood@gmail.com</email>
        <affiliation>Punjab Social Security Health Management Company Hospital</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Pakistan</country2>
      <country2>Pakistan</country2>
    </countries>
    <criteria>
      <inclusion_criteria>having metabolic syndrome according to ATP III CRITERIA
Both gender age 30 to 50 years</inclusion_criteria>
      <agemin>30 years</agemin>
      <agemax>50 years</agemax>
      <gender>Both</gender>
      <exclusion_criteria>Type I diabetes
Heart failure
Renal problems
Mal-absorption syndrome
History of bariarrtic surgery
Participants who were taking weight loss medications
Smoker,
alcohol intake
Pregnant or lactation</exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code>E88.81</hc_code>
      <hc_code>E78.4</hc_code>
      <hc_code>E08</hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword>Metabolic syndrome</hc_keyword>
      <hc_keyword>Other hyperlipidemia</hc_keyword>
      <hc_keyword>Diabetes mellitus due to underlying condition</hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Treatment - Other</i_code>
      <i_code>Treatment - Other</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>Intervention group: follows Resistance exercises( 6 days a week ): exercise starts with 30% repetition maximum of resistance exercise training on multiple exercise units, 3 sets of 9 exercises, six times per week with 10 repetitions, 1 min rest between sets. The load will be adjusted every month according to the 70% 1RM rule.9 resistance exercises that will be followed during 12 weeks on multiple exercise units are listed below1.	Front raises2.	Shoulder shrug3.	Bicep curl4.	Seated dumbbell press5.	Lateral raises6.	Pull down7.	Leg extension curl8.	Seated row9.	Chest press23</i_keyword>
      <i_keyword>control group: Endurance exercises: 30 min per day( 6 days a week ) of endurance exercise training on the treadmill, intensity will be adjusted through HRmax.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Hyperlipidemia. Timepoint: hyperlipidemia will  be measured before and after 12 weeks of treatment. Method of measurement: hyperlipidemia will be measured through laboratory blood test.</prim_outcome>
      <prim_outcome>Sugar levels. Timepoint: sugar levels will be measured before and after 12 weeks of treatment. Method of measurement: sugar levels will be measured through laboratory blood test.</prim_outcome>
      <prim_outcome>Uric acid. Timepoint: uric acid will be measured before and after 12 weeks of treatment. Method of measurement: uric acid will be measured through laboratory blood test.</prim_outcome>
      <prim_outcome>Waist circumference. Timepoint: waist circumference will be measured before and after 12 weeks of treatment. Method of measurement: waist circumference will be measured with measuring tape.</prim_outcome>
      <prim_outcome>Blood pressure. Timepoint: blood pressure will  be measured before and after 12 weeks of treatment. Method of measurement: blood pressure will be measured through mercury blood pressure apparatus.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome>Pain. Timepoint: pain will be measured before and after 12 weeks of treatment. Method of measurement: pain will be measured through visual analogue scale.</sec_outcome>
      <sec_outcome>Body mass index. Timepoint: body mass index will be measured before and after 12 weeks of treatment. Method of measurement: body mass index will be measured by measuring height and weight of individual.</sec_outcome>
      <sec_outcome>VO2MAX. Timepoint: vo2max will be measured before and after 12 weeks of treatment. Method of measurement: vo2max will be measured by rockport walking fitness test.</sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>sarwat anees</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2022-09-01</approval_date>
        <contact_name>Ethics committee of sharif medical and dental college lahore</contact_name>
        <contact_address>Sharif polyclinic, near doce bakers, railway road raiwind Lahore punjab Pakistan</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
