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IRCT20091012002581N9 IRCT 2023-02-21 Tabriz University of Medical Sciences Comparison of topical ۵% Methimazole and 4 % Hydroquinone effect on melasma Comparison of the effect of topical Methimazole 5% versus topical Hydroquinone 4% on the improvement of melasma lesions 2023-03-06 anticipated 30 Complete https://irct.ir/trial/66154 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Factorial, Purpose: Treatment. 2-3 melasma. Intervention 1: Intervention group: 5% topical methymazole cream that has been formulated in Tabriz University of Medical Sciencses Faculty of Pharmacy, is provided to the patients and they are asked to apply this cream to the right side of their cheek once a day. Patients are followed up at intervals of 4, 8, and 12 weeks, and their recovery rate, satisfaction, and Masi score are checked for them. Thyroid function tests are also requested again in the 8th week. The side effects and recovery rate will be checked based on the mentioned cases at the end of the 12th week. Intervention 2: Control group: 5% topical hydroquinone cream that has been formulated in Tabriz University of Medical Sciences Faculty of Pharmacy,is provided to the patients and they are asked to apply this cream to the right side of their cheek once a day. Patients are followed up at intervals of 4, 8, and 12 weeks, and their recovery rate, satisfaction, and Masi score are checked for them. Thyroid function tests are also requested again in the 8th week. The side effects and recovery rate will be checked based on the mentioned cases at the end of the 12th week. Yes - There is a plan to make this available What will be shared: The data of the study are classified and coded so that the names of the people cannot be identified. When: Access starts from the beginning of data collection November 1401 To whom: For researchers in academic institutions Conditions: In order to use in other studies Where to obtain: To me, Hamida Harizchi Ghadim, all the ways of communication have been mentioned in the previous section Priority through phone call , Email and then SMS Shaghayegh Babapoor through phone call, SMS and E-mail How to obtain: After receiving the request via phone call or SMS and email, it will be sent within a week. Comments:
public Dr Hamideh Herizchi- Ghadim
Dermatology ward , Sina hospital,Azadi street, Tabriz
Tabriz Iran (Islamic Republic of) 5166614766 +98 41 1540 6612 dr.herizchi@yahoo.com Tabriz University of Medical Sciences scientific dr Hamideh Herizchi- Ghadim
Dermatology ward, Sina hospital, Azadi street , Tabriz
Tabriz Iran (Islamic Republic of) 5166614766 +98 41 1540 6612 dr.herizchi@yahoo.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Age higher than 18 years and below 50 years Informed consent participate in the study Presence of melanoma in both sides of cheeks 18 years 50 years Both Lack of consent to participate in the study Pregnancy or lactation History of sensitivity to Tiamazoles Thyroid dysfunction History of using other topical drugs for melanoma in past 3 months L81.1 Chloasma Treatment - Drugs Treatment - Drugs Intervention group: 5% topical methymazole cream that has been formulated in Tabriz University of Medical Sciencses Faculty of Pharmacy, is provided to the patients and they are asked to apply this cream to the right side of their cheek once a day. Patients are followed up at intervals of 4, 8, and 12 weeks, and their recovery rate, satisfaction, and Masi score are checked for them. Thyroid function tests are also requested again in the 8th week. The side effects and recovery rate will be checked based on the mentioned cases at the end of the 12th week. Control group: 5% topical hydroquinone cream that has been formulated in Tabriz University of Medical Sciences Faculty of Pharmacy,is provided to the patients and they are asked to apply this cream to the right side of their cheek once a day. Patients are followed up at intervals of 4, 8, and 12 weeks, and their recovery rate, satisfaction, and Masi score are checked for them. Thyroid function tests are also requested again in the 8th week. The side effects and recovery rate will be checked based on the mentioned cases at the end of the 12th week. Severity of melasma lesions. Timepoint: 1, 4, 8 and 12 months after treatment. Method of measurement: Clinical examination and comparison of photos and use of Hemi Masi score. Tabriz University of Medical Sciences Approved 2022-11-22 Vice Chancellor for research of Tabriz University of Medical Sciences Research centre , 3th floor, Central building number 2,Tabriz University of Medical Sciences,Golgasht street ,Tabriz Tabriz East Azarbaijan Iran (Islamic Republic of)