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IRCT20221230056991N1 IRCT 2023-01-11 Esfahan University of Medical Sciences Investigating the effect of platelet-rich plasma in androgenetic alopecia (PRP(platelet-rich plasma Comparison of the effectiveness of combined treatment of topical minoxidil and PRP(platelet rich plasma) with topical minoxidil alone in patients with moderate to severe female androgenetic alopecia referred to educational clinics Isfahan University of Medical Sciences 2022-12-26 anticipated 60 Complete https://irct.ir/trial/67864 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: First, the patients will be included in the study by convenience sampling method. Then the patients are randomly divided into 2 main groups. In each group, we use the limited randomization method of the block randomization type, in such a way that the groups consist of 15 blocks of 4, including 2 A and 2 B. 3 Androgenetic alopecia. Intervention 1: Control group: Receive topical minoxidil foam 5% once a day. Intervention 2: Intervention group: Receiving topical minoxidil foam 5% once a day and injecting platelet-rich plasma 3 sessions at one-month intervals. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Arezoo Refaghat
Safa Street, Al Zahra Hospital, Skin Clinic
Isfahan Iran (Islamic Republic of) 8168613446 +98 31 3668 8644 arezoorefaghat@gmail.com Esfahan University of Medical Sciences scientific Arezoo Refaghat
Safa Street, Al Zahra Hospital, Skin Clinic
Isfahan Iran (Islamic Republic of) 8168613446 +98 31 3668 8644 arezoorefaghat@gmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Patients willing to participate in the study Confirmatory diagnosis of androgenetic alopecia disease by two experts with skin and hair experience Women aged 18 to 60 years Moderate to severe hair loss 18 years 60 years Female Patients suffering from other types of alopecia (such as alopecia areata, telogen effluvium, anagen effluvium and scarring alopecias) Patients with active psoriasis or active lichen planus due to the positive Köbner phenomenon in these diseases Any serious systemic disease L64 Androgenic alopecia Treatment - Drugs Treatment - Other Control group: Receive topical minoxidil foam 5% once a day Intervention group: Receiving topical minoxidil foam 5% once a day and injecting platelet-rich plasma 3 sessions at one-month intervals Increase density and thickness of hair. Timepoint: The beginning of the study and 6 months after the start of the study. Method of measurement: Trichogram, standard photography. Patient satisfaction score, doctor satisfaction score. Timepoint: The beginning of the study and 6 months after the start of the study. Method of measurement: A 10-point questionnaire is assigned for the patient's satisfaction, as well as a 10-point questionnaire that is completed by the doctor based on the comparison of the standard photography score and the comparison of the trichogram (checking the thickness and density of the hair). Esfahan University of Medical Sciences Approved 2022-12-25 Ethical Committee of Isfahan University of Medical Sciences Hazarjarib Street, Isfahan University of Medical Sciences Isfahan Isfehan Iran (Islamic Republic of)