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IRCT20210823052264N2 IRCT 2023-02-06 PNS SHIFA Efficacy of Acyclovir in Pityriasis rosea Efficacy of Acyclovir in Pityriasis rosea, a double blind randomized controlled trial in a tertiary care hospital in Pakistan. 2023-02-10 anticipated 60 Complete https://irct.ir/trial/68311 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Lottery method in the form of sealed envelopes, Blinding description: The participant, principle investigator, outcome assessors and care givers will all be blinded except for one physician who will open the sealed envelope and give the patient drug or placebo, as per the group code inside the envelope, without informing the patient if he is being given the drug or placebo. 3 Pityriasis rosea. Intervention 1: Intervention group: In group “A” patients were treated with oral acyclovir 800mg 5 times/day for a duration of 7 days. Intervention 2: Intervention group: In group “B” patients were treated with placebo pill (glucose) 5 times/day daily for a duration of 7 days. Yes - There is a plan to make this available What will be shared: Primary outcome When: 1 month after publication and for life time. To whom: People Working in academic institutions Conditions: Many Where to obtain: najiaomer@yahoo.com How to obtain: Request Comments:
public Najia Ahmed
Dr najia ahmed 5th floor OPD tower PNS shifa hospital
Karachi Pakistan 74900 +92 81 2864092 najiaomer@yahoo.com PNS shifa scientific Najia Ahmed
Dr najia ahmed 5th floor OPD tower PNS shifa hospital
Karachi Pakistan 74900 +92 81 2864092 najiaomer@yahoo.com PNS shifa Pakistan Patients presenting with pityriasis rosea within first week of eruption of papulosquamous rash. Either gender between Age 12-70 years. 12 years 70 years Both Positive venereal disease research laboratory (VDRL) test. Females with pregnancy or lactation. Patients who have taken any other specific treatment for PR in last 01 week. Patients with any cause of immunosuppression like chronic renal failure, diabetes mellitus, HIV positive and malignancy etc. L42 Pityriasis rosea Treatment - Drugs Placebo Intervention group: In group “A” patients were treated with oral acyclovir 800mg 5 times/day for a duration of 7 days Intervention group: In group “B” patients were treated with placebo pill (glucose) 5 times/day daily for a duration of 7 days. Clinical Response based on clearance of lesions. Timepoint: Patients in both the groups were evaluated clinically on 7th and 14th day of treatment. Method of measurement: Clinical Response Evaluation. PNS SHIFA Approved 2023-02-01 Ethical Review Committee, PNS shifa PNS Shifa Hospital, DHA phase 2, Karachi Karachi sind Pakistan