IRCT20230427058007N1 IRCT 2023-08-14 Riphah International University Effect of weight bearing functional exercises and non-weight bearing quadriceps strengthening along with breathing exercises in people with knee osteoarthritis and obesity. Effect of weight bearing functional exercises and non-weight bearing quadriceps strengthening along with breathing exercises on pain, functional activity, stress, lipid profile , cellular hypoxia and BDNF levels in people with knee osteoarthritis and obesity. 2023-01-01 anticipated 30 Complete https://irct.ir/trial/70009 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: No, Randomization description: Even Odd method was used for Randomization. even group numbers was enrolled as group A and odd group numbers was enrolled as Group B, Blinding description: The care provider was blinded to the groups of the study as well as the outcome Accessor was also blinded to the treatment protocols and study hypothesis. N/A osteoarthritis. Intervention 1: Intervention group 1: non weight bearing quardiceps strengthening exercises along with breathing exercises for 6 weeks. Each session will last 30–40 min. Participants will be provided with adjustable ankle cuff weights (0.65 kg to 10 kg) and elastic resistance bands. They will commence the program with two sets of ten repetitions for each exercise for the first 2 weeks and progress to three sets thereafter or as quickly as able. The starting weight will be the participant’s 10-repetition maximum weight or determined by the participant’s level of effort aiming for between 5 and 8 out of 10 (hard to very hard) on the modified Borg Rating of Perceived Exertion CR-10 scale for strength training . Intervention 2: Intervention group 2: weight bearing functional exercises along with breathing exercises for 6 weeks. Each session will last 30–40 min. . Participants will be provided with an adjustable step (10 cm to 15 cm height), foam mat, and elastic resistance bands. A major emphasis is on the quality of performance of each exercise. Participants will be instructed to maintain alignment of the pelvis and trunk in the frontal plane (avoid pelvic drop and trunk lateral flexion) and to neutrally align their knee (position the knee over the foot as much as possible) throughout the movements. Knee flexion should not exceed 30° (except when performing the chair stand exercise) to reduce the risk of increasing knee pain. Having hand support within easy reach or using hand support is important for maintaining balance and quality of performance throughout the movements. Exercise progression is essential and is determined by the physiotherapist, based on a combination of the participant’s pain and rating of perceived exertion score for each exercise (at least 5 out of 10 on a modified Borg Rating of Perceived Exertion CR-10 scale) and the physiotherapist’s assessment of the quality of the exercise performance. No - There is not a plan to make this available Justification or reason for not sharing IPD is we have recruited the data and completed the trial because things have to be streamline later