]>
IRCT20220501054712N1 IRCT 2023-09-25 Islamic Azad University Comparison of the effects of two types of resistance training on hypoxia-inducible factor-1 (HIF-1a), vascular endothelial growth factor, nitric oxide and endothelin-1. BFR Comparison of the effect of 8 weeks of resistance training with and without blood flow restriction on hypoxia-inducible factor-1 (HIF-1a), vascular endothelial growth factor, nitric oxide and endotelin-1 in men with prehypertension. 2023-10-07 anticipated 36 Complete https://irct.ir/trial/71906 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Diagnostic, Randomization description: A simple randomization method is used in this study. Randomization is run using random number tables. A table of random digits is a set of numbers that have been generated fully randomly without any pattern or specified order, and tabulated. First, an identifying number is assigned to each subject. This way, each person is identified by a number from 00 to 35. The researcher then randomly divides these numbers between three groups: intervention and control groups using a random digits table as follows. Upon the attendance of subjects, the researcher starts to read the numbers of the table. The subjects are assigned to the groups as follows: The first read identification number between 00 and 35 is assigned to the first intervention group (obstructive training group), the second number to the second intervention group (without obstructive training group), and the third number to the control group. This number assignment continues until 12 subjects are assigned to each group. N/A primary hypertension. Intervention 1: Intervention group 1: the high intensity resistance training without blood flow restriction for 8 weeks, 3 sessions per week with an intensity of 75% of one rep-max. Intervention 2: Intervention group 2: the low intensity resistance training with blood flow restriction for 8 weeks, 3 sessions per week with an intensity of 30% of one rep-max. Intervention 3: Intervention group 3: the low intensity resistance training without blood flow restriction for 8 weeks, 3 sessions per week with an intensity of 30% of one rep-max (control group). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The information has not been completed yet.
public Ali Yari
No. 17, Unit 17, Block 5, Milad Building, Daneshjoo Blvd.,
Ilam Iran (Islamic Republic of) 693994565 +98 918 343 6046 Aliyari9090@yahoo.com Islamic Azad University scientific Ali Yari
No. 17, Unit 17, Block 5, Milad Building, Daneshjoo Blvd.,
Ilam Iran (Islamic Republic of) 6931994565 +98 918 343 6046 Aliyari9090@yahoo.com Islamic Azad University Iran (Islamic Republic of) Men with prehypertension Physical and mental health Having no history of regular sport activity during the previous two years Informed personal consent to participate in the study 30 years 45 years Male Having no cardiovascular diseases Having no oncological diseases Having no hormonal diseases Having no acute or chronic diseases Not being addicted to drugs and cigarettes No medication intake I10 Essential (primary) hypertension Other Other Other Intervention group 1: the high intensity resistance training without blood flow restriction for 8 weeks, 3 sessions per week with an intensity of 75% of one rep-max. Intervention group 2: the low intensity resistance training with blood flow restriction for 8 weeks, 3 sessions per week with an intensity of 30% of one rep-max. Intervention group 3: the low intensity resistance training without blood flow restriction for 8 weeks, 3 sessions per week with an intensity of 30% of one rep-max (control group). Hypoxia-inducible factor-1 (HIF-1a). Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method. Vascular endothelial growth factor. Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method. Nitric oxide. Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method. Endotelin-1. Timepoint: The tests will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training and after 10-12 hours of fasting. Method of measurement: After samples coagulation and serum centrifugation, the serum levels of variables are determined using the ELISA method. Blood pressure. Timepoint: two months. Method of measurement: Measurements will be done in two stages: one day before the first training session (pre-test) and 48 hours after the last training session (post-test), on the 8th week of training using pressure gauge device. Islamic Azad University Approved 2023-07-19 Islamic Azad University Kermanshah Branch Farhikhtegan Blvd., Ferdowsi Sq., Kermanshah Kermanshah Kermanshah Iran (Islamic Republic of)