<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT20230202057310N2</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2023-08-29</date_registration>
      <primary_sponsor>Muhammad Nawaz Sharif University of Agriculture</primary_sponsor>
      <public_title>Mulligan traction straight leg raise stretch and proprioceptive exercise in treating osteoarthritis</public_title>
      <acronym></acronym>
      <scientific_title>Therapeutic utility of Mulligan traction straight leg raise stretch and proprioceptive exercise in treating osteoarthritis</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2023-08-31</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>130</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/72189</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Patients were assessed by radiological finding (x-ray) and by physical assessment and by monitoring of biochemical parameters, Randomization description: Allocation concealment occurs and patients will be recruited by using simple randomization through the Lottery method. lottery method carried out through sealed envelopes. Also the data analyser will be kept blind to minimize biasness, Blinding description: Participants will be blinded. Participants will be unaware of the type of treatments that will be evaluated after the completion of the intervention trial. Subjects will be completely unaware of the type and effects of both interventions. And in the same way data analyser will be kept blind by not knowing about the effects and group details.</study_design>
      <phase>1</phase>
      <hc_freetext>Knee osteoarthritis with grade 1,2 and 3.</hc_freetext>
      <i_freetext>Intervention 1: Intervention group:  Group A will receive proprioceptive exercises, half squats, standing on just one foot, walking on the heel and toes (with eyes open and closed), one-legged balance exercises using a heating pad, and knee flexion and extension exercises while sat in a chair. Proprioceptive Exercise group A will be given 3 sessions/week for 8 weeks, with a total of 24 sessions, each lasting 45 minutes. The exercises in their program will develop from static to dynamic, including single-leg stances and balance exercises on unstable surfaces, starting with low-to-moderate intensity balance and stability exercises. Every exercise will be done for 1 to 2 minutes, with a 30-second break in between. Intervention 2: Intervention group:  Group-B The total treatment regimen will be 8 weeks, including 24 sessions, participants in the Mulligan Traction Straight Leg Raise Stretch (MT-SLR) group B get the intervention 3 times a week for 30 minutes each session. Every session will involve performing 3 sets of 10 repetitions of straight leg lifts while using manual traction. The traction force will be adjusted according to each individual's comfort level and the repetitions were held for 15–20 seconds each. Intervention 3: Intervention group:  Group C will be given both proprioceptive and MT-SLR The total treatment regimen will be 8 weeks, including 24 sessions, participants in the Mulligan Traction Straight Leg Raise Stretch (MT-SLR)  get the intervention 3 times a week for 30 minutes each session. Proprioceptive Exercise group will be given in 3 sessions/week for 8 weeks, with a total of 24 sessions, each lasting 45 minutes.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan>Yes - There is a plan to make this available</results_IPD_plan>
      <results_IPD_description>What will be shared:
The title is COMPARATIVE ANALYSIS OF MULLIGAN AND PROPRICEPTIVE EXERCISES IN KNEE OSTEOARTHRITIS.

When:
N/A

To whom:
N/A

Conditions:
N/A

Where to obtain:
N/A

How to obtain:
N/A

Comments:
N/A</results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Saman Iqbal</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>HBL street, sbzazar station, Bosan road, Multan, Pakistan</address>
        <city>Multan</city>
        <country1>Pakistan</country1>
        <zip>66000</zip>
        <telephone>034350467357</telephone>
        <email>samaniqbal2019@gmail.com</email>
        <affiliation>Muhammad Institute of Medical and Allied Sciences, Multan, Pakistan</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Imran Ahmad Khan</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Agriculture Complex, Old Shuja Abad Rd,</address>
        <city>Multan</city>
        <country1>Pakistan</country1>
        <zip>66000</zip>
        <telephone>+92 333 6120602</telephone>
        <email>imranahmadkhandurrani@gmail.com</email>
        <affiliation>Muhammad Nawaz Sharif University of Agriculture</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Pakistan</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Age 40-65 years
Patients with diagnosed OA
Both genders
Patients with swelling in knee joints
Patients with pain in knee joints
Difficulty in walking and climbing stairs</inclusion_criteria>
      <agemin>40 years</agemin>
      <agemax>65 years</agemax>
      <gender>Both</gender>
      <exclusion_criteria>Vascular neoplasia
Fibromyalgia
Radiculopathy
Neuropathy
Joint fractures
Vestibular problems
Congenital disorders
Tumor</exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code>M17</hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword>Osteoarthritis of knee</hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Treatment - Other</i_code>
      <i_code>Treatment - Other</i_code>
      <i_code>Treatment - Other</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>Intervention group:  Group A will receive proprioceptive exercises, half squats, standing on just one foot, walking on the heel and toes (with eyes open and closed), one-legged balance exercises using a heating pad, and knee flexion and extension exercises while sat in a chair. Proprioceptive Exercise group A will be given 3 sessions/week for 8 weeks, with a total of 24 sessions, each lasting 45 minutes. The exercises in their program will develop from static to dynamic, including single-leg stances and balance exercises on unstable surfaces, starting with low-to-moderate intensity balance and stability exercises. Every exercise will be done for 1 to 2 minutes, with a 30-second break in between.</i_keyword>
      <i_keyword>Intervention group:  Group-B The total treatment regimen will be 8 weeks, including 24 sessions, participants in the Mulligan Traction Straight Leg Raise Stretch (MT-SLR) group B get the intervention 3 times a week for 30 minutes each session. Every session will involve performing 3 sets of 10 repetitions of straight leg lifts while using manual traction. The traction force will be adjusted according to each individual's comfort level and the repetitions were held for 15–20 seconds each.</i_keyword>
      <i_keyword>Intervention group:  Group C will be given both proprioceptive and MT-SLR The total treatment regimen will be 8 weeks, including 24 sessions, participants in the Mulligan Traction Straight Leg Raise Stretch (MT-SLR)  get the intervention 3 times a week for 30 minutes each session. Proprioceptive Exercise group will be given in 3 sessions/week for 8 weeks, with a total of 24 sessions, each lasting 45 minutes.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Pain and functional disability. Timepoint: 8 weeks. Method of measurement: Numerical Pain Rating Scale, Pain catastrophizing scale, The Western Ontario and McMaster Universities Arthritis Index (WOMAC).</prim_outcome>
      <prim_outcome>Range of motion. Timepoint: 8 weeks. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index (WOMAC).</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome>Inflammatory biomarkers. Timepoint: 8 weeks. Method of measurement: Complete blood count (CBC) and interleukins measurement.</sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>Muhammad Nawaz Sharif University of Agriculture</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2023-07-30</approval_date>
        <contact_name>The Institutional Ethical Committee of Muhammad Institute of Medical and Allied Sciences, Multan</contact_name>
        <contact_address>HBL street, Sbzazar metro station, Bosan road, Multan, Pakistan Multan Punjab Pakistan</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
