IRCT20230202057310N3 IRCT 2023-09-07 Muhammad Institute of Medical and Allied Sciences, Multan Berberis Aristata and Metformin in Diabetic Patients Synergistic Effect of Berberis Aristata and Metformin in Diabetic Patients-A Randomized Controlled Trial 2023-09-10 anticipated 295 Complete https://irct.ir/trial/72403 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: We used sealed envelops for lotterty method and randomization of participants was done. Randomization of participants in groups by lottery method Simple randomization, Blinding description: Double blinded study was done by keeping blind i-e the physiotherapist as Investigator and data analyser to avoid biasness and ro get the authentic results. 1-2 Diabetes Mellitus. Intervention 1: Intervention group: Group A will be treated with Berberis aristata (550 mg twice a day) orally. The treatment regimen will be 6 weeks. Blood glucose, blood pressure, blood cholesterol, respiration rate, heart rate, ketone bodies, HbA1c, DDS score and oxygen saturation of all the patients with diabetes type-2 at baseline and after 6 weeks. Intervention 2: Intervention group: Group B will be given metformin orally (500 mg). The treatment regimen will be 6 weeks. Blood glucose, blood pressure, blood cholesterol, respiration rate, heart rate, ketone bodies, HbA1c, DDS score and oxygen saturation of all the patients with diabetes type-2 at baseline and after 6 weeks. Intervention 3: Intervention group: Group C will be given both Berberis aristata and metformin (550/250 mg once). The treatment regimen will be 6 weeks. Blood glucose, blood pressure, blood cholesterol, respiration rate, heart rate, ketone bodies, HbA1c, DDS score and oxygen saturation of all the patients with diabetes type-2 at baseline and after 6 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is N/A