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IRCT20151123025202N33 IRCT 2023-10-27 Hamedan University of Medical Sciences The effect of tacrolimus ointment and timolol solution in the treatment of post-acne erythema Comparison of the effect of 0.1% tacrolimus ointment with 0.5% timolol solution in the treatment of Post Acne erythema 2023-11-22 anticipated 86 Complete https://irct.ir/trial/73317 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: We made 86 cards and write letter TA on 43 for tacrolimus and on the other 43 letter TI for the timolol group. Then put them inside the envelope with aluminum wrap and put in a box. At the time of patient arrival, one of the envelopes randomly will be selected and open it, based on selected letter ( TA or TA) patients will be assigned to tacrolimus or timolol group, Blinding description: The person analyzing the data will analyze the groups as A and B and will be blind of the type of prescription drugs. A and B codes will be disclosed after the statistical analysis is completed. 3 Acne vulgaris. Intervention 1: Intervention group: Tacrolimus ointment 0.1% will be used topically once a night for 8 weeks. Intervention 2: Intervention group: 0.5% timolol maleate solution will be used topically once a night for a period of 8 weeks. Yes - There is a plan to make this available What will be shared: All data can be shared except for authors names When: From 2024 onwards it is permissible To whom: Clinical professionals and Researchers in all fields Conditions: To develop research and science Where to obtain: Correspond to the email address of the scientific responsible for the study How to obtain: Send and receive email Comments:
public Abbas Moradi
Community medicine department, Medical School, Shahid Fahmideh Ave
Hamadan Iran (Islamic Republic of) 6517838736 +98 81 3838 0557 a.moradi@umsha.ac.ir Hamedan University of Medical Sciences scientific Dr Mohammad Jamshidi
Mirzadeh Eshghi
Hamadan Iran (Islamic Republic of) 6517838736 +98 81 3264 0030 jamshidim84@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Age above 18 years Consent to participate in the study 18 years no limit Both History of allergy to tacrolimus and timolol History of using anti-acne drugs within 3 months before the treatment process Pregnant and lactating mothers bronchial asthma, severe COPD, sinus bradycardia, 2nd and 3rd degree heart block and heart failure L70.0 Acne vulgaris Treatment - Drugs Treatment - Drugs Intervention group: Tacrolimus ointment 0.1% will be used topically once a night for 8 weeks. Intervention group: 0.5% timolol maleate solution will be used topically once a night for a period of 8 weeks. Erythema. Timepoint: Before treatment, at the end of week 4 and at the end of week 8 of treatment. Method of measurement: Take a picture of lesions and and compare based on Clinical Erythema Assessment scale by dermatologist. Side effects of itching, burning, scaling and redness. Timepoint: 4th and 8th week of treatment. Method of measurement: Clinical examination and asking the patient about complications. Hamedan University of Medical Sciences Approved 2023-10-19 ethics committee of Hamedan University of medical science Shahid Fahmide Ave Hamadan Hamadan Iran (Islamic Republic of)