The main objective of the study: the effect of oral Salvia officinalis extracts capsules on metabolic parameters, oxidative stress and general health in women with polycystic ovary syndrome / study method: randomized clinical trial, placebo-controlled, triple-blind. /
Samples: all Iranian women with polycystic ovary syndrome who were referred to infertility and gynecology clinics of the Firouzgar hospital and approved private centers having at least two of three Rotterdam consensus criteria will participate. Women should not have taken any food supplements, hormonal drugs (except oral contraceptive compounds), reducing or increasing the weight compounds, The blood lipid lowering drugs, The blood glucose lowering drugs and Anti-epileptic drugs should not have been used during the study and two months before it and patients with chronic physical diseases and mentally disorders, addicted to drugs and having allergy to salvia officinalis, will be excluded.
After approval of ethical committee of Iran University of Medical Sciences all patients will give their written informed consents and then the samples with triple-blind manner will be randomly divided into two groups: treatment with oral salvia officinalis extract or placebo. Before any intervention all participants will fill the Demographic information questionnaire, Health history form and GHQ28 ( general health questionnaire ) and after 12 to 14 hours of fasting 10 cc of blood will be collected to measure glucose, insulin, cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL) , triglycerides and markers of oxidative stress (MDA, TAC) from each participant. The experimental group who will receive salvia officinalis alcoholic extract 150 mg capsules twice a day orally and the control group will take similar capsules with Starch as a placebo for 8 weeks. After 2 months of study blood will be taken from all subjects for assessment metabolic and oxidative stress markers and GHQ-28 questionnaire will be filled again.