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IRCT20231101059927N1 IRCT 2023-11-07 PNS Shifa Karachi HACOR score in predicting non-invasive ventilation failure Using HACOR score in predicting failure of non-invasive ventilation in patient with Type-I respiratory failure 2022-12-01 anticipated 180 Complete https://irct.ir/trial/73588 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Not used, Assignment: Single, Purpose: Diagnostic, Blinding description: Blinded of the study protocol and given a standard monitoring chart to endorse vitals and clinical variables to be later assessed by the outcome assessor. 2 Type-I respiratory failure. Intervention group: HACOR SCORE GROUP. Yes - There is a plan to make this available What will be shared: Word document of the manuscript along with output sheet of SPSS software would be made available When: After acceptance for publication, data will be available online indefinitely To whom: Academic and research institutes only Conditions: For research, academic and teaching purposes only Where to obtain: Will be available online through google drive How to obtain: A written request to the primary author and the institute training branch and after acceptance and permission data would be made available in the next 5 working days and a temporary google drive link will be shared to download the data in the next one week Comments:
public Ali Aftab
Dha phase 2
Karachi Pakistan 24700 +92 300 2509354 alijiwani512@hotmail.com PNS Shifa Hospital Karachi scientific Ali Aftab
Dha phase 2
Karachi Pakistan 24700 +92 300 2509354 alijiwani512@hotmail.com PNS Shifa Hospital Karachi Pakistan Patients with Pa02/FiO2 levels < 300 mmHg and PaCO2 levels less than 45 mmHg with PaO2 and PaCO2 (calculated by ABG (arterial blood gas) analysis) at room air or not maintaining ratio at low oxygenation therapy after administration of oxygen at FiO2 of 0.30 no limit no limit Both Patients with severe cardiorespiratory compromise Critical patients on vasopressor support Patients with poor lung compliance unable to breath in CPAP Intubated patients or those intubated less than 1 hour of CPAP Patients with a previous failed CPAP trial or on HFNO (high flow nasal oxygenation) in the last 72 hours Patients non-compliant on CPAP despite sedation Patients unwilling to be included in the study J96.0 Acute respiratory failure Early detection Intervention group: HACOR SCORE GROUP Failure of NIV after 1-hour on CPAP therapy. Timepoint: 1 hour after CPAP therapy. Method of measurement: Standard HACOR score. Sensitivity and specificity of HACOR in predicting NIV failure. Timepoint: 1 hour after being on CPAP therapy. Method of measurement: Assessment using standard SPSS software. Postive and negative predictive value of the HACOR test in assessing NIV failure. Timepoint: 1 hour after being on CPAP therapy. Method of measurement: Standard statistical SPSS software. Heart rate and mean arterial pressure. Timepoint: Before and after 1 hour of CPAP therapy. Method of measurement: Cardiac monitor. Respiratory rate. Timepoint: Before and after 1 hour of CPAP therapy. Method of measurement: Standard respiratory monitor. Glasgow coma scale. Timepoint: Before and after 1 hour of CPAP therapy. Method of measurement: Standard Glasgow coma scale. Pa02/FiO2 ratio. Timepoint: Before and after 1 hour of CPAP therapy. Method of measurement: Using arterial blood gas samples and standard calculating formula. PNS Shifa Karachi Approved 2022-11-30 Ethical Review Board PNS Shifa Karachi PNS Shifa Karachi Sindh Pakistan