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IRCT20191025045235N2 IRCT 2023-12-13 Ahvaz University of Medical Sciences Comparative study effect of Dexmedetomidine and Ketamine on post operative analgesia after laparoscopic cholecystectomy the Comparative study effect of Dexmedetomidine and Ketamine on post operative analgesia after laparoscopic cholecystectomy surgery 2024-01-21 anticipated 252 Complete https://irct.ir/trial/74152 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: People were divided into two groups completely randomly based on the random block permutation method. For example, for blocks of four, we imagined 6 blocks ABBA, AABB, ABAB, BABA, BBAA, BAAB, which should be n/4 We sampled from these blocks in the form of placement. The random sequence was obtained from the website www.sealedenevelope.com. Patients are entered in the order of entry.Patients are randomly divided into three groups (ketamine, dexmedetomidine and control).Group: K In this group, 0.5 mg/kg/h of ketamine (Panpharma, Germany) is injected intravenously 15 minutes before surgical incision. Group: D In this group, 0.6 µ/kg/min dexmedetomidine (Exir Company, Iran) is injected intravenously 15 minutes before surgical incision, Blinding description: the patient and the anesthesia technician are unware of the type of injected drug.the medicine is already prepare and given to the technician. 3 cholesystit. Intervention group:Patients are randomly divided into three groups (ketamine, dexmedetomidine and control). Group K: In this group, 0.5 mg/kg/h of ketamine (Panpharma, Germany) is injected intravenously 15 minutes before surgical incision. Group D: In this group, 0.6 µ/kg/min of dexmedetomidine (Exir Company, Iran) is injected intravenously 15 minutes before surgical incision. Group C: In this group, normal saline is injected intravenously.. Yes - There is a plan to make this available What will be shared: Only part of the data, such as information about the main outcome or the like, can be shared. When: The access period starts 6 months after the results are published To whom: It will be available only to researchers working in academic and scientific institutions. Conditions: Researcher's request to conduct similar studies Where to obtain: Request by sending an email to the responsible administrator How to obtain: Sending an email to the responsible executive and explaining the procedure, then sending the data to her Comments:
public Seyedeh Fatemeh Hosseininejad
Imam Khomeini Hospital,Azadegan Ave,Ahvaz
Ahvaz Iran (Islamic Republic of) 6135913441 +98 916 615 2270 drhosseininejad@yahoo.com Ahvaz University of Medical Sciences scientific Seyedeh Fatemeh Hosseininejad
Imam Khomeini Hospital,Azadegan Ave,Ahvaz
Ahvaz Iran (Islamic Republic of) 6135913441 +98 916 615 2270 drhosseininejad@yahoo.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) patients with ASA class I and II patients age between 18 and 50 years 18 years 50 years Both emergency surgery sensitivity to the drugs used in the study abuse or alcohol lack of consent to participate in the study sychiatric disorder patients who, for some reason, changed their operation from laparoscopic during surgery. The surgery is open. G89.18 Other acute postprocedural pain Treatment - Drugs Intervention group:Patients are randomly divided into three groups (ketamine, dexmedetomidine and control). Group K: In this group, 0.5 mg/kg/h of ketamine (Panpharma, Germany) is injected intravenously 15 minutes before surgical incision. Group D: In this group, 0.6 µ/kg/min of dexmedetomidine (Exir Company, Iran) is injected intravenously 15 minutes before surgical incision. Group C: In this group, normal saline is injected intravenously. Pain. Timepoint: 1-2-4-6 hours after the surgery. Method of measurement: After visiting the operating room and initial examinations, all patients will have an intravenous line with an 18 size angioket. Initial monitoring will include pulse oximetry, non-invasive sphygmomanometer, and electrocardiography. Initial symptoms will be recorded and treated with midazolam 0.03 drugs. mg/kg, fentanyl 2 µgr/kg, sodium thiopental 5 mg/kg and atracurium 0.5 mg/kg are placed under anesthesia induction and then intubated,They are connected to a ventilator and are anesthetized with isoflurane 1 ml during the operation and 0.1 mg/kg morphine is given to reduce pain during the operation. The patients are randomly divided into three groups (ketamine, dexmedetomidine and control). Group K: 15 minutes before surgical incision, 0.5 mg/kg/h of ketamine (Panpharma, Germany) is injected intravenously. Group D: In this group, 15 minutes before surgical incision, 0.6 µ/kg/min of dexmedetomidine (Exir, Iran) is injected into It is injected intravenously.Group C: In this group, normal saline is injected intravenously. Primary hemodynamic parameters such as heart rate and blood pressure are recorded upon arrival, immediately after receiving the study drugs, every 5 minutes to 15 minutes, and every 15 minutes until the end of the procedure. Next, the hemodynamic parameters and duration of painlessness, VAS score will be recorded at 24, 12, 6, 1 hours after the operation. 0 no pain), up to (VAS=10, the worst type of pain after surgery). If the score is higher than 3 after the surgery, painkillers will be prepared and injected (morphine 2-3 mg). Blood pressure and heart rate changes. Timepoint: Every 15 minutes during operation. Method of measurement: With pressure gauge and monitoring device. Ahvaz Jundishapur University of Medical Sciences Approved 2023-08-12 Ethics committee of Ahvaz Jundishapur University of Medical Sciences Imam Khomeini Hospital,Azadegan Ave,Ahvaz Ahvaz Khouzestan Iran (Islamic Republic of)