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IRCT20240430061607N1 IRCT 2024-06-06 Debre Markos University Impact of Exercise on Metabolism in Overweight/Obese Adults Metabolic Impact of Exercise Modalities in Inactive Overweight and Obese Adults: A Randomized Controlled Trial 2022-03-20 anticipated 24 Complete https://irct.ir/trial/76528 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Factorial, Purpose: Treatment, Randomization description: In our clinical trial, randomization was achieved through simple random sampling, with individuals as the unit of randomization. A computerized random number generator created a sequence to allocate participants to their respective groups, ensuring each had an equal chance of assignment. Allocation concealment was implemented using sealed opaque envelopes, which were opened only after baseline assessments, to prevent selection bias and uphold the study’s integrity, Blinding description: The outcome assessors and data analysts were masked to the group assignments of participants. This was achieved by assigning codes to participant groups that were only known to researchers. The assessors and analysts worked with these codes, devoid of any knowledge regarding which group each code represented. This method effectively prevented potential bias in the assessment of outcomes and the analysis of data, thereby upholding the integrity of the research findings. 2-3 Condition 1: glucose intolerance. Condition 2: dyslipidemia. Intervention 1: Intervention group 1: Aerobic exercise training group. Participants in the AT group engaged in treadmill exercise at 50-75% of their maximum heart rate for 25-40 minutes, 3 times per week. Intervention 2: Intervention group 2: resistance Exercise training group. The RT group performed 6 major muscle exercises targeting major muscle groups at 50–75% of their 1-RM, 3 times per week. Intervention 3: Control group: concurrent training group. The CT group combined the total volume of both the RT and AT groups, performing endurance exercises followed by strength exercises in each session. No - There is not a plan to make this available Justification or reason for not sharing IPD is The datasets generated and/or analyzed during the current study are not publicly available due to data security before publication but are available from the corresponding author on reasonable request.
public Friew Amare
Abima, Debre Markos
Debre Markos Ethiopia no +251 58 771 6070 firewa6070@gmail.com Debre Markos University scientific Yehualaw Alemu
Abima, Debre Markos
Debre Markos Afghanistan no +251 58 771 6070 yehualaw@gmail.com Debre Markos University Ethiopia Had a BMI > 24.9 kg/m2 Were aged between 45 and 60 years Volunteered to participate Were physically inactive (not achieving 30–60 min per day or 150 min per week of moderate intensity exercise or 20–60 min per day (75 min per week) of vigorous intensity and cleared a medical history form the physical activity readiness questionnaire) Were able to perform the necessary exercises 45 years 60 years Male Any cardiovascular, respiratory, or muscle-skeletal disorders precluding physical exercise Uncontrolled hyperglycemia (≥ 126 mg/d) Uncontrolled hypertension (a resting blood pressure ≥140/100 mm hg) Active infection Acute myocardial infarction, stroke, trauma, surgery or severe liver dysfunction Treatment - Other Treatment - Other Treatment - Other Intervention group 1: Aerobic exercise training group. Participants in the AT group engaged in treadmill exercise at 50-75% of their maximum heart rate for 25-40 minutes, 3 times per week. Intervention group 2: resistance Exercise training group. The RT group performed 6 major muscle exercises targeting major muscle groups at 50–75% of their 1-RM, 3 times per week. Control group: concurrent training group. The CT group combined the total volume of both the RT and AT groups, performing endurance exercises followed by strength exercises in each session. Glucose tolerance. Timepoint: before intervention and at the end of eighth week. Method of measurement: GOTT tests were analyzed by the hexokinase method (COBAS, Roche), and its intracoefficient of variation ranged between 1.58% (µ=64.7 mg/dl) and 1.38% (µ=369 mg/dl). Lipid profile. Timepoint: before intervention and at the end of eighth week. Method of measurement: An enzymatic method utilizing an Alpha X autoanalyzer with E2HL-100 kits and a sensitivity of 0.1 mmol/dL (Hitachi, Tokyo, Japan) was employed for lipid measurement. Body composition. Timepoint: before intervention and at the end of eighth week. Method of measurement: body fat percentage were determine by abdominal, thigh, suprailiac and triceps skinfolds measurements on the right side of the body to the nearest 0.5 mm with a Lange caliper (Cambridge Scientific Instruments, Cambridge, MD, USA). and determined by sari equation. Debre Markos University Approved 2022-01-15 Debre Markos University Sport Science Academy Ethics committee Abima, Debre Markos Debre Markos Amhara Ethiopia