IRCT201109107520N1 IRCT 2011-12-29 Vice Chancellor for research, Kermanshah University of Medical Sciences (KUMS) Extra-Amniotic Normal Saline Infusion plus Hydrocortisone versus Prostaglandin E2 Suppository for Pregnancy Termination EASI Comparison of Extra-Amniotic Normal Saline Infusion plus Hydrocortisone versus Prostaglandin E2 Suppository for Pregnancy Termination 2004-04-20 anticipated 50 Complete https://irct.ir/trial/8006 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Induction of labor, termination of pregnancy. Intervention 1: Prostaglandin group (25 patients) was received two doses of prostaglandin E2 intra vaginal suppository (Dinoprostone) 3mg every 4 hour. In both groups, 6 hours after the last dose of prostaglandin and removal of Foley catheter, induction with high dose Oxytocin (according to Alabama University Protocol) was initiated up to 24 hours maximum. Intervention 2: In EASHI group (25 patients), under sterile conditions, a coworker inserted a No. 14 Foley catheter through the cervical canal and balloon was filled with 20 ml water and fixed. Then 360 ml sterile Normal Saline with 100 mg. Hydrocortisone was infused at a rate of 30 ml per hours into the extra amniotic space. The Foley catheter was checked every hour for spontaneous expulsion. If it was tolerated by patients, the infusion continued up to 12 hours maximum. In both groups, 6 hours after the last dose of prostaglandin and removal of Foley catheter, induction with high dose Oxytocin (according to Alabama University Protocol) was initiated up to 24 hours maximum.