IRCT20100718004409N16 IRCT 2025-02-04 Iran University of Medical Sciences Mesenchymal stem cell in rotator cuff tear The evaluation of effectiveness of mesenchymal stem cell derived from autologous adipose tissue compared to platelet rich plasma on pain and functionality of the patients with total tear of shoulder rotator cuff tendons (The second phase of a clinical trial) 2025-03-05 anticipated 30 Complete https://irct.ir/trial/81157 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization is base on block randomization. The 30 participants divided in five blocks, each includes six. Three patients will take PRP and three patients will take stem cells in each group. The allocation of each one in each block is based on opening the envelops that determine type of intervention, Blinding description: Analyzer of the data is blinded to the intervention groups. 2 Full tear of shoulder rotator cuff tendon. Intervention 1: Intervention group: First, 20 to 30 cc of fat is collected via liposuction in sterile conditions from the abdomen and flank areas of the patient and sent to the hospital's Motahari Clean Room laboratory for preparation. Flow cytometry tests are performed, and CD markers are checked. After the mesenchymal cells are prepared (2 to 3 months after the process begins), the sample will be sent to the sports medicine department of Rasoul Akram Hospital. At the same time, 1 cc of the solution containing the prepared cells will be injected into the torn tendon under ultrasound guidance. Intervention 2: Control group: For preparing Platelet Rich Plasma, 35 cc of venous blood will be drawn from the patients and placed in a centrifuge. The separated plasma from the first centrifugation for 10 minutes at 1600 Revolutions Per Minute (RPM) will be drawn in the tubes, and the second centrifugation will last for 6 minutes at 3200 RPM. Then, 3 cc from the end of each tube, after removing the upper plasma, will be drawn into a syringe. The injection will be performed under ultrasound guidance into the tear tendon. No - There is not a plan to make this available Justification or reason for not sharing IPD is The plan will be design after starting the study