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IRCT20250430065545N1 IRCT 2025-08-14 Esfahan University of Medical Sciences Effects of Transcranial Direct Current Stimulation on Athletic Performance Investigation of the Effects of Transcranial Direct Current Stimulation on Athletic Performance: A Comparison Between Primary Motor Cortex and Dorsolateral Prefrontal Cortex 2025-05-22 anticipated 17 Complete https://irct.ir/trial/83341 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Other, Blinding description: Participant: On one of the intervention days, transcranial direct current stimulation is applied in a non-realistic manner and the participant is unaware of the method of application of the stimulation. Evaluator: The person evaluating the consequences of the intervention is unaware of the type and location of transcranial direct current stimulation applied to the subjects. N/A Strength, muscular endurance, and perceived exertion in strength athletes. Intervention Group 1: Primary Motor Cortex (M1) Stimulation:Anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1).Stimulation parameters: Current intensity of 2 mA for 20 minutes. The anode electrode will be placed over the M1 region (according to the 10-20 EEG system), and the cathode (return) electrode will be placed over the contralateral supraorbital region.Intervention Group 2: Dorsolateral Prefrontal Cortex (DLPFC) Stimulation:Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC).Stimulation parameters: Current intensity of 2 mA for 20 minutes. The anode electrode will be placed over the DLPFC region, and the cathode (return) electrode will be placed over the contralateral supraorbital region.Intervention Group 3: Sham Stimulation:Sham transcranial direct current stimulation (tDCS).Stimulation parameters: Electrode placement will be similar to one of the active conditions (e.g., M1 or DLPFC, randomly). The current will be applied for a short duration (30 seconds) and then turned off, while the device remains on, to allow the participant to experience the initial sensation of stimulation; however, active stimulation will not continue throughout the 20-minute duration.This study is a randomized, double-blind, crossover clinical trial. Each participant will receive all three intervention conditions (M1 stimulation, DLPFC stimulation, and Sham stimulation) in separate sessions and in a randomized order. A washout period of 2 days will be observed between each intervention session.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The decision regarding the sharing of individual participant data (IPD) requires careful consideration of ethical implications, obtaining further informed consent, and establishing a clear protocol for de-identification and controlled data access. Currently, a specific plan for this purpose has not been developed, but the possibility of exploring this after the study's completion, while fully adhering to ethical principles and protecting participant privacy, will be considered.
public Mohammad Hossein Shafiezadeh
Unit 3, Mah Complex, Pega Alley, Khwarizmi 1st Street, Ghadir Boulevard, Sepahan Shahr, Isfahan
isfahan Iran (Islamic Republic of) 8179918639 +98 31 3653 1491 shafiezadeh@rehab.mui.ac.ir Esfahan University of Medical Sciences scientific Dr. Navid Taheri
Room 324, Department of Physiotherapy, School of Rehabilitation Sciences, Isfahan University of Medical Sciences and Health Services, Hezar Jerib St. isfahan
isfahan Iran (Islamic Republic of) 81746-73461 +98 31 3792 5049 n_taheri@rehab.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) At least 6 months of experience in resistance training Right feet dominant 18 years 30 years Male History of musculoskeletal injury in lumbar, hip, or knee Use of hormonal injection such as steroids in the last 3 months Use of creatine supplement in the last 1 month Rehabilitation Intervention Group 1: Primary Motor Cortex (M1) Stimulation:Anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1).Stimulation parameters: Current intensity of 2 mA for 20 minutes. The anode electrode will be placed over the M1 region (according to the 10-20 EEG system), and the cathode (return) electrode will be placed over the contralateral supraorbital region.Intervention Group 2: Dorsolateral Prefrontal Cortex (DLPFC) Stimulation:Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC).Stimulation parameters: Current intensity of 2 mA for 20 minutes. The anode electrode will be placed over the DLPFC region, and the cathode (return) electrode will be placed over the contralateral supraorbital region.Intervention Group 3: Sham Stimulation:Sham transcranial direct current stimulation (tDCS).Stimulation parameters: Electrode placement will be similar to one of the active conditions (e.g., M1 or DLPFC, randomly). The current will be applied for a short duration (30 seconds) and then turned off, while the device remains on, to allow the participant to experience the initial sensation of stimulation; however, active stimulation will not continue throughout the 20-minute duration.This study is a randomized, double-blind, crossover clinical trial. Each participant will receive all three intervention conditions (M1 stimulation, DLPFC stimulation, and Sham stimulation) in separate sessions and in a randomized order. A washout period of 2 days will be observed between each intervention session. Maximum Voluntary Contraction (MVC): Maximum isometric force produced by the quadriceps femoris muscle. Muscular Endurance: Maximum number of correct repetitions of knee extension exercise with a specific load (30-40% of 1-RM) until complete exhaustion. Rate of Perceived Exertion (RPE): Subjective assessment of an individual's perceived level of difficulty and strain associated with the physical activity performed. Timepoint: Before and immediately after each intervention session (anodal tDCS over M1, anodal tDCS over DLPFC, and sham tDCS). Method of measurement: Maximum Voluntary Contraction (MVC): Using a handheld dynamometer, while the subject is seated on a knee extension machine with the knee flexed at a 90-degree angle. The subject is instructed to extend the knee with maximal effort for 5 seconds. This process is repeated 3 times with a one-minute rest interval, and the highest value is recorded.Muscular Endurance: Using a leg extension machine. Subjects are asked to lift a weight equivalent to 30-40% of their 1-RM until they can no longer perform additional repetitions. The number of completed repetitions is recorded.Rate of Perceived Exertion (RPE): Using the Borg's RPE scale (ranging from 6 to 20), reported by the subject after the muscular endurance test. Esfahan University of Medical Sciences Approved 2025-04-30 Ethics committee of isfahan University of Medical Sciences Unit 3, Mah Complex, Pega Alley, Khwarizmi 1st Street, Ghadir Boulevard, Sepahan Shahr, Isfahan isfahan Isfehan Iran (Islamic Republic of)