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IRCT20151123025202N46 IRCT 2025-07-29 Hamedan University of Medical Sciences The effect of hormone therapy on tinnitus in menopausal women Evaluation of the effect of hormone replacement therapy on tinnitus in menopausal women. 2025-08-23 anticipated 40 Complete https://irct.ir/trial/85112 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: For the purpose of randomization, 40 cards are prepared, 20 of which are labeled with the letter A and 20 with the letter B, and each card is placed in an aluminum envelope and placed inside a box. When the patients arrive, one of the envelopes will be randomly selected and opened. Based on the letter selected inside, the patient will be assigned to group A or B, Blinding description: In this study, the placebo will be prepared in a similar shape and color to the original drug. The drug and placebo will be identified by a code. The patient and the person evaluating the treatment outcome will be unaware of the type of treatment. 2-3 Tinnitus. Intervention 1: Intervention group: They will receive 0.625 mg of conjugated estrogens and 2.5 mg of medroxyprogesterone daily for three months. Intervention 2: Control group: They will receive one placebo pill (containing starch) daily, which will be packaged in a form and appearance similar to estrogen, for 3 months. Yes - There is a plan to make this available What will be shared: All data can be shared except for authors names When: From 2026 onwards it is permissible To whom: Clinical professionals and Researchers in all fields Conditions: For treatment of patients and develop research and science Where to obtain: Correspond to the email address of the scientific responsible for the study How to obtain: Send and receive email Comments:
public Abbas Moradi
Shahid Fahmideh
Hamadan Iran (Islamic Republic of) 6515974544 +98 81 3838 0097 a.moradi@umsha.ac.ir Hamedan University of Medical Sciences scientific Farhad Farahani
Shahid Beheshti Blv
Hamadan Iran (Islamic Republic of) 6514845411 009881338274184 h_farahani@umsha.ac.ir Hamedan University of Medical Sciences Iran (Islamic Republic of) Female gender Menopause within the last 10 years Having the patient's consent to participate in the study 50 years no limit Female Having depression History of calcium, vitamin, and magnesium intake two months before intervention Tinnitus caused by medication side effects Suspicion and diagnosis of tumoral lesions Patients with conductive or mixed hearing loss H93.1 Tinnitus Treatment - Drugs Placebo Intervention group: They will receive 0.625 mg of conjugated estrogens and 2.5 mg of medroxyprogesterone daily for three months. Control group: They will receive one placebo pill (containing starch) daily, which will be packaged in a form and appearance similar to estrogen, for 3 months. Change in the intensity of tinnitus. Timepoint: Before treatment and at the end of the third month of treatment. Method of measurement: With visual analog scale. Changes in disability scores due to tinnitus. Timepoint: Before treatment and at the end of the third month of treatment. Method of measurement: With the Tinnitus Tinnitus Handicap Inventory (THI). Loudness and frequency of tinnitus. Timepoint: Before treatment and at the end of the third month of treatment. Method of measurement: Audiometric test. Occurrence of drug side effects. Timepoint: During treatment. Method of measurement: Questioning the patient. Hamedan University of Medical Sciences Approved 2025-07-08 Ethics committee of Hamadan Univercity of Medical Science ُSahahid Fahmideh Hamadan Hamadan Iran (Islamic Republic of)