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IRCT20250507065634N13 IRCT 2026-01-01 The University of Guilan The effect of resistance and aerobic training on patients with multiple sclerosis. The effect of resistance and aerobic training on growth hormones cortisol, insulin-like growth factor 1, and depression in women with relapsing-remitting multiple sclerosis. 2026-01-08 anticipated 40 Complete https://irct.ir/trial/87271 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Education/Guidance, Randomization description: After selecting the sample (40 eligible volunteers), all individuals are numbered. For randomization, opaque, light-tight, and sealed envelopes are used. Before the study begins, 40 envelopes are prepared, inside of which are placed equal numbers of papers labeled “Aerobic Exercise Test Group,” “Resistance Exercise Test Group,” and “Control Group.” The order of the papers in the envelopes is randomized, and the envelopes are then sealed. Upon entering the study, each individual randomly selects an envelope and is assigned to the experimental or control group based on its contents. This process ensures that the assignment of individuals to groups is completely random and that there is no possibility of prediction or interference in the assignment by the researcher or participants. N/A Multiple sclerosis. Intervention 1: Control group: 10 participants who meet the inclusion criteria will be randomly assigned to the study as the control group. They will complete a depression questionnaire. ELISA will measure growth hormone, cortisol, and insulin-like growth factor levels before and after the intervention. However, they will not participate in any exercise. Intervention 2: First intervention group: 10 patients with multiple sclerosis referred to Besat Hospital in Rasht, who meet the inclusion criteria and are randomly assigned to participate in the study as the intervention group. They complete a depression questionnaire, and their growth hormone, cortisol, and insulin-like growth hormone levels are measured by ELISA and blood tests before starting the exercises. Then, they are placed in strength training sessions for 30-40 minutes for 24 sessions, 3 sessions per week, over 3 weeks. Before starting the sessions, 6 training sessions will be completed. The exercises are strength-based, and 5-10 minutes are dedicated to warming up (walking and stretching), 25-35 minutes to basic weight-bearing exercises, and 5 minutes to cool down (stretching). After completing the sessions, their growth hormone, cortisol, and insulin-like growth hormone levels are measured again by ELISA and blood tests after the exercises. Intervention 3: Second intervention group: The second intervention group consists of 10 women with relapsing–remitting multiple sclerosis who are referred to Ba’ath Hospital in Rasht and meet the inclusion criteria. Participants are randomly assigned to this group. At baseline, participants complete the Beck Depression Inventory (BDI), and serum levels of growth hormone, cortisol, and insulin-like growth factor 1 are measured before the initiation of the intervention through blood sampling using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Subsequently, participants undergo an aerobic exercise training program for 8 weeks, with two sessions per week, totaling 16 sessions. Before the main intervention, 6 instructional sessions are conducted to familiarize participants with the correct performance of the exercises. Each aerobic exercise session lasts 20 to 40 minutes and consists of three parts to 10 minutes of warm-up (including walking and stretching exercises),20 to 30 minutes of the main exercise (walking), and 5 minutes of cool-down (stretching exercises). Exercise intensity is individually prescribed and monitored during the sessions based on the Borg Rating of Perceived Exertion (RPE) scale. After completion of the exercise program, serum levels of growth hormone, cortisol, and insulin-like growth factor 1 are re-measured through blood sampling using the ELISA method. Intervention 4: Intervention group: Third intervention group: 10 people with multiple sclerosis referred to Besat Hospital in Rasht, who meet the inclusion criteria and are randomly assigned to participate in the study as the intervention group. They complete a depression questionnaire and their growth hormone, cortisol, and insulin-like growth hormone levels are measured by ELISA and blood tests before starting the exercises. Then, they participate in combined aerobic and resistance training sessions at each person's home. The duration of the sessions is 28 sessions, 2 sessions per week. After completing the sessions, their growth hormone, cortisol, and insulin-like growth hormone levels are measured again by ELISA and blood tests after the exercises. Yes - There is a plan to make this available What will be shared: Demographic data and the main outcome results of the research can be shared after de-identification and preserving the privacy of individuals. When: Data can be made available 4 months after the results are published and after personally identifiable information is removed. To whom: The study data and documentation will be available to researchers and scholars working at reputable academic and scientific institutions. Conditions: Research data and documentation may be used for scientific and research purposes. Users must undertake to keep non-identifiable data confidential. Where to obtain: If you need data, please contact How to obtain: After receiving and reviewing the request from the researcher, the request will be responded to as soon as possible. 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public Faeze Alipour
Ahmadi Sabet, 10th Alley, Jomhouri Street, Lahijan, Gilan Province, Iran
Lahijan Iran (Islamic Republic of) ۴۴۱۹۸۸۵۱۳۶ +98 937 156 1655 faezealipour2@gmail.com The University of Guilan scientific Payam Saidie
University Complex of Guilan, Km 5 Tehran Road, Khalij-e Fars Expressway, Rasht, Iran
Rasht Iran (Islamic Republic of) 4199613776 +98 911 194 3804 payam.saidie@gmail.com The University of Guilan Iran (Islamic Republic of) Age range between 25 and 50 years Women with depression in the Beck Depression Inventory range of 21-63 (BDI) Having depressive disorder with a severity of 0–5 on the DPEI scale Having regular menstrual cycles Not using antidepressant medications Disease severity (EDSS) between 0.5 and 5.5 No history of thyroid, renal, cardiovascular, or vascular diseases Having at least a 2-month interval since the last exercise training Non-smoker No alcohol consumption Having a relapsing-remitting type of Multiple Sclerosis (MS) 25 years 50 years Female Recurrence of the disease Feeling of pain Lack of necessary balance during the exercises Participation in physiotherapy, massage therapy and rehabilitation programs in the last three months History of cardiovascular diseases, epilepsy and migraines G35 Multiple sclerosis Diagnosis Diagnosis Diagnosis Diagnosis Control group: 10 participants who meet the inclusion criteria will be randomly assigned to the study as the control group. They will complete a depression questionnaire. ELISA will measure growth hormone, cortisol, and insulin-like growth factor levels before and after the intervention. However, they will not participate in any exercise. First intervention group: 10 patients with multiple sclerosis referred to Besat Hospital in Rasht, who meet the inclusion criteria and are randomly assigned to participate in the study as the intervention group. They complete a depression questionnaire, and their growth hormone, cortisol, and insulin-like growth hormone levels are measured by ELISA and blood tests before starting the exercises. Then, they are placed in strength training sessions for 30-40 minutes for 24 sessions, 3 sessions per week, over 3 weeks. Before starting the sessions, 6 training sessions will be completed. The exercises are strength-based, and 5-10 minutes are dedicated to warming up (walking and stretching), 25-35 minutes to basic weight-bearing exercises, and 5 minutes to cool down (stretching). After completing the sessions, their growth hormone, cortisol, and insulin-like growth hormone levels are measured again by ELISA and blood tests after the exercises. Second intervention group: The second intervention group consists of 10 women with relapsing–remitting multiple sclerosis who are referred to Ba’ath Hospital in Rasht and meet the inclusion criteria. Participants are randomly assigned to this group. At baseline, participants complete the Beck Depression Inventory (BDI), and serum levels of growth hormone, cortisol, and insulin-like growth factor 1 are measured before the initiation of the intervention through blood sampling using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Subsequently, participants undergo an aerobic exercise training program for 8 weeks, with two sessions per week, totaling 16 sessions. Before the main intervention, 6 instructional sessions are conducted to familiarize participants with the correct performance of the exercises. Each aerobic exercise session lasts 20 to 40 minutes and consists of three parts to 10 minutes of warm-up (including walking and stretching exercises),20 to 30 minutes of the main exercise (walking), and 5 minutes of cool-down (stretching exercises). Exercise intensity is individually prescribed and monitored during the sessions based on the Borg Rating of Perceived Exertion (RPE) scale. After completion of the exercise program, serum levels of growth hormone, cortisol, and insulin-like growth factor 1 are re-measured through blood sampling using the ELISA method. Intervention group: Third intervention group: 10 people with multiple sclerosis referred to Besat Hospital in Rasht, who meet the inclusion criteria and are randomly assigned to participate in the study as the intervention group. They complete a depression questionnaire and their growth hormone, cortisol, and insulin-like growth hormone levels are measured by ELISA and blood tests before starting the exercises. Then, they participate in combined aerobic and resistance training sessions at each person's home. The duration of the sessions is 28 sessions, 2 sessions per week. After completing the sessions, their growth hormone, cortisol, and insulin-like growth hormone levels are measured again by ELISA and blood tests after the exercises. Depression. Timepoint: Before intervention and immediately after completion of the intervention. Method of measurement: Beck Depression Inventory (BDI). The University of Guilan Approved 2021-09-20 Research Ethics Committee of the Sports Sciences Research Institute No. 3, 5th Alley, Miremad Street, Motahhari Street, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)