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IRCT20210423051054N2 IRCT 2026-03-01 Shahid Beheshti University of Medical Sciences The Effect of PRGF on Meniscal Degeneration The Effect of Plasma Rich in Growth Factors on Meniscal Degeneration in Knee Osteoarthritis 2026-03-06 anticipated 52 Complete https://irct.ir/trial/88465 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this clinical trial, 52 patients will be randomly enrolled in the study. Random Allocation software will be used to randomly allocate the samples. Using this software, random sequences will be created. For concealment, the random allocation concealment method will be used. In this method, the created sequences will be recorded on cards and these cards will be placed inside sealed envelopes. Then, based on the order in which the eligible individuals entered the study, each envelope will be opened and their assigned number will be determined. 3 Meniscal degeneration. Intervention 1: Control group: Routine treatments for knee osteoarthritis include anti-inflammatory medication (500 mg of Naproxen every 12 hours), reducing knee strain through lifestyle changes, and strengthening the quadriceps muscle. Intervention 2: Intervention group: Routine treatments plus two intra-articular injections of PRGF, which will be administered one month apart. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.
public Rasa Salmani Oshnari
Shohadaye Tajrish Hospital, Shahrdari St, Tajrish Sq
Tehran Iran (Islamic Republic of) 1989934148 +98 21 25719 rasa_salmani@yahoo.com Shahid Beheshti University of Medical Sciences scientific Rasa Salmani Oshnari
Shohadaye Tajrish Hospital, Shahrdari St, Tajrish Sq
Tehran Iran (Islamic Republic of) 1989934148 +98 21 25719 rasa_salmani@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Individuals with knee pain Age between 40 and 60 years Meniscal degeneration detected on MRI 40 years 60 years Both History of significant knee trauma Biomechanical abnormalities of the knee Meniscus or ligament tears History of rheumatic diseases History of septic arthritis of the knee Systemic diseases or medications that affect platelet count or function. Malignancy or any severe systemic disease M23.3 Other meniscus derangements Treatment - Drugs Treatment - Drugs Control group: Routine treatments for knee osteoarthritis include anti-inflammatory medication (500 mg of Naproxen every 12 hours), reducing knee strain through lifestyle changes, and strengthening the quadriceps muscle. Intervention group: Routine treatments plus two intra-articular injections of PRGF, which will be administered one month apart. Meniscal degeneration on MRI. Timepoint: Before treatment and 4 months after the start of treatment. Method of measurement: Magnetic Resonance Imaging. Pain, clinical symptoms, activities of daily living, function, and quality of life. Timepoint: Before treatment and 4 months after the start of treatment. Method of measurement: KOOS questionnaire. Shahid Beheshti University of Medical Sciences Approved 2023-03-05 Ethics committee of Shahid Beheshti University of Medical Sciences Shahid Beheshti University of Medical Sciences, Yaman St, Shahid Chamran Hwy Tehran Tehran Iran (Islamic Republic of)