]>
IRCT20190719044274N2 IRCT 2026-06-15 Tehran University of Medical Sciences A comparative study of the effectiveness of prp and prf injections under ultrasound guidance in improving the symptoms and performance of patients with Osteoarthritis A comparative study of the effectiveness of prp and prf injections under ultrasound guidance in improving the symptoms and performance of patients with Osteoarthritis (Grade 2 and 3 according to the Kellgren-Lawrence classification) 2025-06-02 anticipated 56 Recruiting https://irct.ir/trial/89386 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The random block model is a generative model for random networks. Randomization unit: individual Randomization layers if stratified randomization is used Randomization tool: such as a random number table, Blinding description: The randomized block model is a generative model for two-group random networks. Randomization unit: individual Randomization tool: such as a random number table With the help of computers, random number tables are prepared. These tables have different names and types. These tables are actually rows and columns of numbers that are randomly determined by the computer. In double-blind studies, not only the participant is unaware of their placement in the intervention and control groups; the follow-up and analyst are also unaware of it. N/A Knee osteoarthritis. Intervention 1: Intervention group: Platelet-rich fibrin belongs to a new generation of hemoconcentrates obtained by centrifugation alone, which provide. GF does not require additives such as heparin or thrombin and allows for slow release. GF has the following bioactive properties: stimulation by PRF, in addition to proliferation, differentiation, chemotaxis and adhesion of stem cells, promotion of vascularization and immune processes, increased expression of alkaline phosphatase in stem cells, which leads to faster mineralization of newly formed tissue. It also contains transforming growth factor beta GF. It also causes direct mineralization and creates an epithelial barrier by the membrane (PDGF) and platelet-derived growth factor (TGF-β1). 15 PRF. Intervention 2: Control group: PRP intra-knee injection PRP preparation method: To prepare PRP, 10 ml of venous blood sample will be taken by centrifugation at 3400 rpm for 15 minutes at room temperature using a Neuation swing rotor centrifuge and 3.5 ml of PRP will be produced. The test tubes will contain sodium citrate solution as an anticoagulant and autologous thrombin as an activator to promote platelet activation and conversion of fibrinogen to fibrin. For quality tests, 0.5 ml of the PRP sample will be sent to the laboratory and 3 ml will be used for ultrasound-guided injection. No - There is not a plan to make this available Justification or reason for not sharing IPD is In the case of individual participant data (IPD) there is no plan to share the data.
public Ebrahim Espahbodi
Keshavaraz Blvd, Gharib Ave, Imam khomeini hospital,Tehran
Tehran Iran (Islamic Republic of) 1416753955 +98 21 6119 0000 Shervinshahinpour@gmail.com Tehran University of Medical Sciences scientific Ebrahim Espahbodi
Keshavaraz Blvd, Gharib Ave, Imam khomeini hospitalTehran
Tehran Iran (Islamic Republic of) 1416753955 +98 21 6119 0000 Shervinshahinpour@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Patients aged 50 to 75 years who have. Patients with knee osteoarthritis grade 2 and 3 according to the Kellgren-Lawrence classification 50 years 75 years Both Exclusion criteria included systemic disease such as diabetes, immunodeficiency, collagen vascular disease, history of malignancy, active infection or wound in the knee, autoimmune diseases, disorders affecting platelets. Hemoglobin < 12 mg/dL or platelets < 150,000/microL, history of severe knee trauma Steroid injection in the knee 3 weeks before surgery, systemic steroid injection in the last 2 weeks Hemoglobin < 12 mg/dL or platelets < 150,000/microL, history of severe knee trauma M17 Osteoarthritis of knee Treatment - Other Treatment - Other Intervention group: Platelet-rich fibrin belongs to a new generation of hemoconcentrates obtained by centrifugation alone, which provide. GF does not require additives such as heparin or thrombin and allows for slow release. GF has the following bioactive properties: stimulation by PRF, in addition to proliferation, differentiation, chemotaxis and adhesion of stem cells, promotion of vascularization and immune processes, increased expression of alkaline phosphatase in stem cells, which leads to faster mineralization of newly formed tissue. It also contains transforming growth factor beta GF. It also causes direct mineralization and creates an epithelial barrier by the membrane (PDGF) and platelet-derived growth factor (TGF-β1). 15 PRF Control group: PRP intra-knee injection PRP preparation method: To prepare PRP, 10 ml of venous blood sample will be taken by centrifugation at 3400 rpm for 15 minutes at room temperature using a Neuation swing rotor centrifuge and 3.5 ml of PRP will be produced. The test tubes will contain sodium citrate solution as an anticoagulant and autologous thrombin as an activator to promote platelet activation and conversion of fibrinogen to fibrin. For quality tests, 0.5 ml of the PRP sample will be sent to the laboratory and 3 ml will be used for ultrasound-guided injection. Improve knee mobility. Timepoint: 2 weeks. Method of measurement: Numeric rating scale questionnaire. Range of motion. Timepoint: 6 w. Method of measurement: Physical examination. Tehran University of Medical Sciences Approved 2026-02-24 Ethics Committee in Biomedical Research, Imam Khomeini Hospital, Tehran University of Medical Scienc Keshavarz blvd Tehran Tehran Iran (Islamic Republic of)